{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:14:13Z","timestamp":1777072453821,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["175067"],"award-info":[{"award-number":["175067"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A high prevalence of insulin resistance (IR) has proven to manifest in patients with adrenal incidentalomas (AI). It has been demonstrated that an increase in IR is related to the size of tumourous masses; additionally, luteinizing hormone (LH)\u2010dependent adrenal pathologies are well documented in patients with LH\u2010responsive adrenal tumours occurring under conditions of physiologically elevated LH. We hypothesized that an association between LH and insulin might play a role in adrenal tumourigenesis and steroidogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The aim of our study was to investigate the association between LH and IR; adrenal tumour size (ATS) and IR; LH and cortisol after the 1\u00a0mg overnight dexamethasone test (1\u00a0mg DST); and ATS and 1\u00a0mg DST cortisol in AI patients. This was a case\u2010control study conducted in the Clinic for Endocrinology, Diabetes and Metabolic Diseases in Belgrade, Serbia. The total study group consisted of 105 menopausal women: 75 AI patients [27 with nonfunctional AI (NAI) and 48 with (possible) autonomous cortisol secretion ((P)ACS)] and 30 age\u2010, BMI\u2010, LH\u2010 and menopause duration\u2010matched healthy control (HC) women. To estimate IR, we used homeostasis model assessment (HOMA\u2010IR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Luteinizing hormone and ATS are in a significant positive correlation with HOMA\u2010IR and 1\u00a0mg DST cortisol in menopausal patients with AI and (P)ACS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data point to a possible cause\u2010effect relationship between LH and insulin in patients with AI and (P)ACS adding to the body of evidence of their involvement in adrenal tumourigenesis and steroidogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13541","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T08:02:37Z","timestamp":1514620957000},"page":"541-548","source":"Crossref","is-referenced-by-count":15,"title":["Luteinizing hormone and insulin resistance in menopausal patients with adrenal incidentalomas: The cause\u2010effect relationship?"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-3664","authenticated-orcid":false,"given":"Ljiljana V.","family":"Marina","sequence":"first","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miomira","family":"Ivovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milina","family":"Tan\u010di\u0107\u2010Gaji\u0107","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Arizanovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Rakovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Milin\u2010Lazovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Informatics  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Kendere\u0161ki","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Mici\u0107","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Vujovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Obesity, Reproductive and Metabolic Disorders Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Centre of Serbia Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344099"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.11.5534"},{"key":"e_1_2_8_4_1","first-page":"637","article-title":"A survey on adrenal incidentaloma in Italy. 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