{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:31:57Z","timestamp":1783488717029,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pheochromocytoma surgery carries a high risk of haemodynamic instability (<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>). However, there are few studies investigating the risk factors for <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> for pheochromocytoma surgery in a Chinese population. Therefore, our objective was to identify preoperative risk factors for <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> during surgery in a Chinese population with pheochromocytoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>In this retrospective study, 134 patients undergoing surgery for pheochromocytoma at a single university\u2010affiliated hospital between November 2002 and July 2017 were enrolled. Demographics, comorbidities, preoperative medical preparation, operation details and perioperative haemodynamics of these patients were retrospectively collected and analysed. Multivariable logistic regression analysis was performed to identify the preoperative risk factors for intraoperative <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>32.8% (44\/134) patients suffered from intraoperative <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>. According to the result of multivariate analysis, tumour diameter &gt;50\u00a0mm (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 2.526; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.163\u20135.485; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.019), diabetes\/prediabetes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.251; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.039\u20134.876; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.040) and preoperative systolic blood pressure fluctuation &gt;50\u00a0mm Hg (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.163; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.051\u20139.522, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.041) were independent predictors for intraoperative <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>. The observed incidence of <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> was 8.9%, 42.6%, 47.8% and 60% when zero, one, two or three risk factors were present, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> is common among Chinese patients undergoing surgery for pheochromocytoma. Our study identified three predictive factors for intraoperative <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>: a large tumour diameter, diabetes\/prediabetes and a great preoperative systolic blood pressure fluctuation. Furthermore, patients are more likely to suffer from <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> when they have more predictive risk factors. Identification of these risk factors can help to improve perioperative management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13544","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T07:12:49Z","timestamp":1514877169000},"page":"498-505","source":"Crossref","is-referenced-by-count":31,"title":["Preoperative risk factors for haemodynamic instability during pheochromocytoma surgery in Chinese patients"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-7266","authenticated-orcid":false,"given":"Minchun","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vascular Center Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong 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