{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:21:26Z","timestamp":1789662086849,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Summary<\/jats:title>Context<\/jats:title>Teriparatide (TPTD<\/jats:styled-content>) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy\u2010 and lactation\u2010associated osteoporosis (PLO<\/jats:styled-content>) characterized by the occurrence of fragility fractures in the third trimester or early postpartum.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the changes in bone mineral density (BMD<\/jats:styled-content>) and bone turnover markers in patients with PLO<\/jats:styled-content> with and without TPTD<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective cohort study.<\/jats:p><\/jats:sec>Patients<\/jats:title>Thirty\u2010two patients with PLO<\/jats:styled-content> who presented with multiple vertebral fractures to a tertiary institution between 2007 and 2015 were included.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Changes in BMD<\/jats:styled-content> at the lumbar spine (LSBMD<\/jats:styled-content>) and proximal femur after 12\u00a0months of daily subcutaneous injections of 20\u00a0\u03bcg TPTD<\/jats:styled-content> (n\u00a0=\u00a027) were assessed. Subjects who rejected the TPTD<\/jats:styled-content> treatment were used as controls (n\u00a0=\u00a05).<\/jats:p><\/jats:sec>Results<\/jats:title>LSBMD<\/jats:styled-content> increased in both subjects treated with TPTD<\/jats:styled-content> and controls, with greater increases in the TPTD<\/jats:styled-content> group (15.5\u00a0\u00b1\u00a06.6% vs 7.5\u00a0\u00b1\u00a07.1%, P<\/jats:italic>\u00a0=\u00a0.020) after adjustment for age and baseline LSBMD<\/jats:styled-content>. During follow\u2010up, serum levels of osteocalcin (OCN<\/jats:styled-content>) and C\u2010telopeptide of type I collagen (CTX<\/jats:styled-content>) increased significantly in the TPTD<\/jats:styled-content> group. In multivariate linear regression models, TPTD<\/jats:styled-content> treatment (adjusted \u03b2\u00a0=\u00a07.92, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.032) and younger age (adjusted \u03b2\u00a0=\u00a01.06, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.046), but not baseline LSBMD<\/jats:styled-content>, body mass index, serum OCN<\/jats:styled-content> level and CTX<\/jats:styled-content> level, were independently associated with greater increases in LSBMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In patients with PLO<\/jats:styled-content>, LSBMD<\/jats:styled-content> at 12\u00a0months increased in both the TPTD<\/jats:styled-content>\u2010treated and control groups. TPTD<\/jats:styled-content> treatment and younger age were associated with greater increases in LSMBD<\/jats:styled-content> irrespective of baseline LSBMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13557","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T15:17:41Z","timestamp":1517498261000},"page":"652-658","source":"Crossref","is-referenced-by-count":60,"title":["Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy\u2010 and lactation\u2010associated osteoporosis"],"prefix":"10.1111","volume":"88","author":[{"given":"Namki","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Severance Hospital Endocrine Research Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Graduate School Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gimpo Woori Hospital Gimpo Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ilsan Hospital Koyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hwa","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Catholic Kwandong University College of Medicine International St. Mary's Hospital Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-5638","authenticated-orcid":false,"given":"Yumie","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Severance Hospital Endocrine Research Institute Yonsei University College of Medicine Seoul 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