{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:48:24Z","timestamp":1769856504395,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Summary<\/jats:title>Purpose<\/jats:title>Primary hypophysitis is a rare disease, with an autoimmune aetiology. As few papers have investigated genetic of hypophysitis, our aim was to evaluate HLA<\/jats:styled-content> status in a single\u2010centre series of patients.<\/jats:p><\/jats:sec>Patients and method<\/jats:title>A retrospective, longitudinal and cross\u2010sectional study was conducted. In consecutive Caucasian patients, clinically or histologically diagnosed for primary autoimmune hypophysitis (PAH), the HLA genotype having been determined. This cohort was compared with a control group. Anti\u2010pituitary and anti\u2010hypothalamus auto\u2010antibodies evaluation was included.<\/jats:p><\/jats:sec>Results<\/jats:title>16 patients were enrolled. Fourteen patients were female (87.5%). According to HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content> status, we found the following: 9 of 16 patients (56.3%) haplotypes that were associated with coeliac disease (CD<\/jats:styled-content>). Among these, 5 carried the DR<\/jats:styled-content>7\u2010DQ<\/jats:styled-content>2 heterozygote haplotype (55.5%) while the remaining ones only the following haplotypes: DR<\/jats:styled-content>3\u2010DQ<\/jats:styled-content>2 homozygote (25%), DR<\/jats:styled-content>4\u2010DQ<\/jats:styled-content>2 heterozygote (25%), DR<\/jats:styled-content>4\u2010DQ<\/jats:styled-content>8 heterozygote (50%) and DR<\/jats:styled-content>4\u2010DQ<\/jats:styled-content>8 homozygote (25%), respectively. A total of 12 CD<\/jats:styled-content>\u2010associated haplotypes were identified. In PAH<\/jats:styled-content>, we found a significantly higher frequency of patients carrying CD<\/jats:styled-content>\u2010associated HLA<\/jats:styled-content> haplotypes as compared to the control group (respectively, 75% vs 48% P<\/jats:italic>\u00a0=\u00a0.03; OR<\/jats:styled-content>: 3.25 95%IC<\/jats:styled-content>:1.1\u201010.3), particularly, for DQ<\/jats:styled-content>2 and DQ<\/jats:styled-content>8 haplotypes. DQ<\/jats:styled-content>2 haplotype was detected in 50% of PAH<\/jats:styled-content> and 38.4% of the control group (P<\/jats:italic>\u00a0=\u00a0.3), while DQ<\/jats:styled-content>8 haplotype in 25% of PAH<\/jats:styled-content> and 7.2% of the control group (P<\/jats:italic>\u00a0=\u00a0.01 OR<\/jats:styled-content>:4.3 95%IC<\/jats:styled-content>:1.3\u201014.7).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our data suggest that PAH<\/jats:styled-content> and CD<\/jats:styled-content> share some HLA<\/jats:styled-content> haplotypes, reinforcing the knowledge of their association. HLA<\/jats:styled-content> haplotypes, particularly DQ<\/jats:styled-content>8, may play a role in PAH<\/jats:styled-content> management and diagnosis, also suggesting the predisposition to other autoimmune diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13566","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T11:52:37Z","timestamp":1518090757000},"page":"692-699","source":"Crossref","is-referenced-by-count":21,"title":["Human leucocyte antigens coeliac haplotypes and primary autoimmune hypophysitis in caucasian patients"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-2392","authenticated-orcid":false,"given":"Sabrina","family":"Chiloiro","sequence":"first","affiliation":[{"name":"Department of Endocrinology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore D.","family":"Capoluongo","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Clinical Biochemistry Catholic University of Sacred Heart Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Tartaglione","sequence":"additional","affiliation":[{"name":"Institute of Radiology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Giampietro","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Medicine Laboratory of Vascular Biology and Genetics Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Arena","sequence":"additional","affiliation":[{"name":"Department of Pathology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"De Marinis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Catholic University School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.04.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149707.12335.8e"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199704000-00010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2004.11.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2169\/internalmedicine.49.3458","article-title":"Lymphocytic hypophysitis with a long latent period from onset of central diabetes insipidus to development of pituitary enlargement","volume":"49","author":"Akahori H","year":"2010","journal-title":"Inter Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01821.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43492"},{"key":"e_1_2_7_9_1","first-page":"327","article-title":"Lymphocytic hypophysitis. 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