{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:37:46Z","timestamp":1791218266866,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/02192"],"award-info":[{"award-number":["PI15\/02192"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>An association of pregnancy outcomes with subclinical hypothyroidism has been reported; however, there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The objective of the study was to evaluate the association of foetal\u2010maternal complications with first trimester maternal Thyrotropin (TSH<\/jats:styled-content>) values.<\/jats:p><\/jats:sec>Design<\/jats:title>A retrospective study in a single tertiary care hospital was performed.<\/jats:p><\/jats:sec>Patients<\/jats:title>A total of 1981 pregnant women were studied during 2012.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Thyrotropin (TSH<\/jats:styled-content>) universal screening was performed between 9 and 12\u00a0weeks of gestation. Outcomes included foetal\u2010maternal complications and newborn health parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>Median TSH<\/jats:styled-content> was 1.72 (0.99\u20102.61) mIU<\/jats:styled-content>\/L. The incidence of perinatal loss, miscarriage and stillbirth was 7.2%, 5.9% and 1.1%, respectively. Median TSH<\/jats:styled-content> of women with and without miscarriage was 1.97 (1.29\u20103.28) vs 1.71 (0.96\u20102.58) mIU<\/jats:styled-content>\/L (P<\/jats:italic>\u00a0=\u00a0.009). Incidence of pre\u2010eclampsia was 3.2%; TSH<\/jats:styled-content> in these women was 2.10 (1.40\u20102.74) vs 1.71 (0.98\u20102.59) mIU<\/jats:styled-content>\/L in those without (P<\/jats:italic>\u00a0=\u00a0.027). TSH<\/jats:styled-content> in women with dystocia in labour was 1.76 (1.00\u20102.53) vs 1.68 (0.94\u20102.59) mIU<\/jats:styled-content>\/L in those who gave birth with normal progression (P<\/jats:italic>\u00a0=\u00a0.044). Women with TSH<\/jats:styled-content> 2.5\u20105.1\u00a0mIU<\/jats:styled-content>\/L had a higher risk of perinatal loss [OR<\/jats:styled-content> 1.589 (1.085\u20102.329)], miscarriage [OR<\/jats:styled-content> 1.702 (1.126\u20102.572)] and premature birth [OR<\/jats:styled-content> 1.39 (1.013\u20101.876)], adjusted by mother's age. There was no association with the other outcomes analysed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There is a positive association between maternal TSH<\/jats:styled-content> in the first trimester of pregnancy and the incidence of perinatal loss and miscarriage. The TSH<\/jats:styled-content> cut\u2010off value of 2.5\u00a0mIU<\/jats:styled-content>\/L identified women with higher adverse pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13575","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T08:26:40Z","timestamp":1518856000000},"page":"728-734","source":"Crossref","is-referenced-by-count":29,"title":["Impact of TSH<\/scp> during the first trimester of pregnancy on obstetric and foetal complications: Usefulness of 2.5 mIU<\/scp>\/L cut\u2010off value"],"prefix":"10.1111","volume":"88","author":[{"given":"Marta","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Arnau de Vilanova Lleida Spain"},{"name":"Institut de Recerca Biom\u00e8dica de Lleida (IRB Lleida) Universitat de Lleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Arnau de Vilanova Lleida Spain"},{"name":"Institut de Recerca Biom\u00e8dica de Lleida (IRB Lleida) Universitat de Lleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-4201","authenticated-orcid":false,"given":"Berta","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Germans Trias i Pujol Badalona Spain"},{"name":"Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol Campus can Ruti Universitat Aut\u00f2noma de Barcelona Badalona Spain"},{"name":"CIBER de enfermedades raras (CIBERER) Instituto de Salud Carlos III Madrid Spain"},{"name":"CIBER de diabetes y enfermedades metab\u00f3licas (CIBERDEM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cecenarro","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Germans Trias i Pujol Badalona Spain"},{"name":"Endocrinology and Nutrition Department Hospital Privado Universitario de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mart\u00ednez\u2010Barahona","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol Campus can Ruti Universitat Aut\u00f2noma de Barcelona Badalona Spain"},{"name":"Paedriatics Department Hospital Universitari Germans Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Palomera","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol Campus can Ruti Universitat Aut\u00f2noma de Barcelona Badalona Spain"},{"name":"Unitat de Recerca Hospital de Matar\u00f3 Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Rius","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Arnau de Vilanova Lleida Spain"},{"name":"Institut de Recerca Biom\u00e8dica de Lleida (IRB Lleida) Universitat de Lleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Lecube","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Arnau de Vilanova Lleida Spain"},{"name":"Institut de Recerca Biom\u00e8dica de Lleida (IRB Lleida) Universitat de Lleida Lleida Spain"},{"name":"CIBER de diabetes y enfermedades metab\u00f3licas (CIBERDEM) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Pelegay","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department Hospital Universitari Arnau de Vilanova Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Paedriatics Department Hospital Universitari Arnau de Vilanova Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00eddac","family":"Mauricio","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department Hospital Universitari Germans Trias i Pujol Badalona Spain"},{"name":"Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol Campus can Ruti Universitat Aut\u00f2noma de Barcelona Badalona Spain"},{"name":"CIBER de enfermedades raras (CIBERER) Instituto de Salud Carlos III Madrid Spain"},{"name":"CIBER de 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