{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:34:38Z","timestamp":1790397278667,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15Aek0109122"],"award-info":[{"award-number":["15Aek0109122"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["26\u2010111"],"award-info":[{"award-number":["26\u2010111"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Summary<\/jats:title>Context<\/jats:title>The current Endocrine Society Guideline suggests that patients aged <35\u00a0years with marked primary aldosteronism (PA<\/jats:styled-content>) and unilateral adrenal lesions on adrenal computed tomography (CT<\/jats:styled-content>) scan may not need adrenal vein sampling (AVS<\/jats:styled-content>) before proceeding to unilateral adrenalectomy. This suggestion is, however, based on the data from only one report in the literature.<\/jats:p><\/jats:sec>Objective<\/jats:title>We sought to determine the accuracy of CT<\/jats:styled-content> findings in young PA<\/jats:styled-content> patients who had unilateral adrenal disease on CT<\/jats:styled-content> with hypokalaemia and elevation of aldosterone.<\/jats:p><\/jats:sec>Design and patients<\/jats:title>We retrospectively studied 358 PA<\/jats:styled-content> patients (n\u00a0=\u00a030, aged <35\u00a0years; n\u00a0=\u00a039, aged 35\u201040\u00a0years; n\u00a0=\u00a0289, aged \u226540\u00a0years) with hypokalaemia and elevation of aldosterone and unilateral disease on CT<\/jats:styled-content> who had successful AVS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Main outcome measure<\/jats:title>Accuracy of CT<\/jats:styled-content> findings is determined by AVS<\/jats:styled-content> findings and\/or surgical outcomes in patients aged <35\u00a0years.<\/jats:p><\/jats:sec>Results<\/jats:title>Concordance of the diagnosis between CT<\/jats:styled-content> and AVS<\/jats:styled-content> was 90% (27\/30) in patients aged <35\u00a0years, 79% (31\/39) in patients aged 35\u201040\u00a0years and 69% (198\/289) in those aged \u226540\u00a0years (trend for P<\/jats:italic>\u00a0<\u00a0.01). Surgical benefit was confirmed in three patients aged <35\u00a0years and in three patients aged 35\u201040\u00a0years with the available surgical data who had discordance between CT<\/jats:styled-content> and AVS<\/jats:styled-content> findings. Collectively, the diagnostic accuracy of CT<\/jats:styled-content> findings was 100% (30\/30) if aged <35\u00a0years and 87% (34\/39) if aged 35\u201040\u00a0years.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Primary aldosteronism patients aged <35\u00a0years with hypokalaemia and elevation of aldosterone and unilateral disease on adrenal CT<\/jats:styled-content> could be spared AVS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13582","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:22:40Z","timestamp":1519244560000},"page":"645-651","source":"Crossref","is-referenced-by-count":70,"title":["Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-287X","authenticated-orcid":false,"given":"Hironobu","family":"Umakoshi","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Graduate School of Medical Science Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nephrology School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Nephrology School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-8645","authenticated-orcid":false,"given":"Takuyuki","family":"Katabami","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology Department of Internal Medicine St. Marianna University School of Medicine Yokohama City Seibu Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-7396","authenticated-orcid":false,"given":"Takamasa","family":"Ichijo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Saiseikai Yokohamashi Tobu Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology and Metabolism Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology and Metabolism Tokyo Medical and Dental University Tokyo 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