{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:23:06Z","timestamp":1790745786397,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Cyproheptadine HC<\/jats:styled-content>l (CyproH) is an appetite\u2010stimulating drug and while it was prescribed for a patient with growth hormone insensitivity syndrome (GHIS<\/jats:styled-content>) for increasing appetite, his height growth was surprisingly increased. Therefore, the aim of this study was to investigate the effect of CyproH on growth parameters of the patients with GHIS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Patients and design<\/jats:title>Twenty patients were enrolled in two prospective cohorts at two different times. Fifteen cases were observed for 1.17\u00a0\u00b1\u00a01.3\u00a0years without treatment (observation period, OP<\/jats:styled-content>). Then, CyproH was administered for 2.2\u00a0\u00b1\u00a02.7\u00a0years (treatment period, TP<\/jats:styled-content>), and growth parameters were compared within these two periods. Five patients who did not receive any treatment for 1\u20108.24\u00a0years (4\u00a0\u00b1\u00a02.9) were the control group.<\/jats:p><\/jats:sec>Results<\/jats:title>Height velocity (HV<\/jats:styled-content>) increased from 1.88\u00a0\u00b1\u00a00.7 to 6.1\u00a0\u00b1\u00a00.8\u00a0cm\/year and HV<\/jats:styled-content>\u2010SDS<\/jats:styled-content> reached from \u22124.5\u00a0\u00b1\u00a00.74 to \u22120.21\u00a0\u00b1\u00a01.2 in OP<\/jats:styled-content> and TP<\/jats:styled-content>, respectively (P<\/jats:italic>\u00a0<\u00a0.001), whereas HV<\/jats:styled-content> and HV<\/jats:styled-content>\u2010SDS<\/jats:styled-content> were 2.2\u00a0\u00b1\u00a01.1\u00a0cm\/yr and \u22124.2\u00a0\u00b1\u00a01.2, respectively, in controls (P<\/jats:italic>\u00a0<\u00a0.001). Height SDS<\/jats:styled-content> was \u22127.0\u00a0\u00b1\u00a01.7 and increased to \u22126\u00a0\u00b1\u00a02.2 after treatment (P<\/jats:italic>\u00a0=\u00a0.002). Gain in height was 2.3\u00a0\u00b1\u00a00.6 SDS<\/jats:styled-content> in 5 patients who were treated for 5.4\u00a0\u00b1\u00a02.8\u00a0years. BMI<\/jats:styled-content>\u2010SDS<\/jats:styled-content> was not significantly changed within two time periods and also in cases and controls.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CyproH caused height growth in the patients with GHIS<\/jats:styled-content>, and therefore, this treatment can be considered as an alternative option to IGF<\/jats:styled-content>\u2010I injection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13594","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T08:46:39Z","timestamp":1520585199000},"page":"880-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel treatment for height growth in patients with growth hormone insensitivity syndrome by cyproheptadine hydrochloride"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-6732","authenticated-orcid":false,"given":"Maryam","family":"Razzaghy\u2010Azar","sequence":"first","affiliation":[{"name":"Hazrat Aliasghar Children's Hospital Iran University of Medical Sciences Tehran Iran"},{"name":"Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular\u2010Cellular Sciences Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Nourbakhsh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Nourbakhsh","sequence":"additional","affiliation":[{"name":"Hazrat Aliasghar Children's Hospital Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(94)P3205-L"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(96)80455-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(99)80080-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1330654"},{"key":"e_1_2_7_6_1","first-page":"152","article-title":"Genetic pituitary dwarfism with high serum concentration of growth hormone\u2013a new inborn error of metabolism?","volume":"2","author":"Laron Z","year":"1966","journal-title":"Isr J Med Sci"},{"key":"e_1_2_7_7_1","first-page":"8","article-title":"Defect of human growth hormone receptors in the liver of two patients with Laron\u2010type dwarfism","volume":"20","author":"Eshet R","year":"1984","journal-title":"Isr J Med Sci"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.8083"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.6.1465"},{"key":"e_1_2_7_10_1","first-page":"277","article-title":"If one daily injection of IGF\u2010I has the same growth\u2010promoting effect as 2 injections per day, why continue to give two injections?","volume":"10","author":"Laron Z","year":"2013","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000467"},{"key":"e_1_2_7_12_1","first-page":"93","volume-title":"Lessons From Laron Syndrome (LS) 1966\u20101992: A Model of GH and IGF\u20101 Action and Interaction","author":"Razzaghy\u2010Azar M","year":"1993"},{"key":"e_1_2_7_13_1","first-page":"53","article-title":"Clinical and hormonal milieu of 9 patients with primary growth hormone insensitivity syndrome and their response to IGF\u2010I generation test","volume":"44","author":"Razzaghy\u2010Azar M","year":"2006","journal-title":"Acta Medica Iranica"},{"key":"e_1_2_7_14_1","unstructured":"NigrinD.Growth Calculator 2.01. 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