{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:28:31Z","timestamp":1774574911603,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["CFH 2018-2-4074"],"award-info":[{"award-number":["CFH 2018-2-4074"]}]},{"name":"Youth Foundation of Peking University First Hospital","award":["2017QN27"],"award-info":[{"award-number":["2017QN27"]}]},{"name":"Thyroid Research Program of Young and Middle-aged Physicians"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Hashimoto's thyroiditis (HT<\/jats:styled-content>) with serum IgG4 concentrations greater than 135\u00a0mg\/dL can be diagnosed as elevated serum IgG4 HT<\/jats:styled-content>. HT<\/jats:styled-content> can also be classified into IgG4 HT<\/jats:styled-content> and non\u2010IgG4 HT<\/jats:styled-content> based on an immunohistochemistry analysis of IgG4. The aim of our study was to determine the relationship between elevated serum IgG4 HT<\/jats:styled-content> and IgG4 HT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Method<\/jats:title>Both thyroid tissues and serum samples stored before pathological examination from 93 patients with HT<\/jats:styled-content> were collected. The serum levels of IgG, IgG4, TgAb IgG, TgAb IgG4, TPOA<\/jats:styled-content>b IgG and TPOA<\/jats:styled-content>b IgG4 were measured by ELISA<\/jats:styled-content>s. The expression levels of IgG4, IgG and TGF<\/jats:styled-content>\u2010\u03b21 in thyroid tissues were detected by immunohistochemistry.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with HT<\/jats:styled-content> were divided into two groups: elevated serum IgG4 HT<\/jats:styled-content> (n\u00a0=\u00a012) and nonelevated serum IgG4 HT<\/jats:styled-content> (n\u00a0=\u00a081). Hypothyroidism was found in 5 of 12 cases (41.7%) in the elevated serum IgG4 HT<\/jats:styled-content> group and 10 of 81 cases (12.3%) in the nonelevated serum IgG4 HT<\/jats:styled-content> group (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.023). Serologically, there were no significant differences in the levels of TgAb IgG, TPOA<\/jats:styled-content>b IgG, TgAb IgG4 and TPOA<\/jats:styled-content>b IgG4 between the two groups, and the expression of TGF<\/jats:styled-content>\u2010\u03b21 in thyroid tissues was not significantly different between the groups. Most importantly, the frequency of patients who satisfied the criteria for IgG4 HT<\/jats:styled-content> diagnosis was comparable (25% vs 20.9%, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.756).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The measurement of serum IgG4 allows the identification of patients with HT<\/jats:styled-content> closely associated with hypothyroidism. However, our study demonstrated that elevated serum IgG4 HT<\/jats:styled-content> is not equivalent to IgG4 HT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13596","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T07:48:36Z","timestamp":1520581716000},"page":"943-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hashimoto's thyroiditis with elevated serum IgG4 concentrations is not equivalent to IgG4 Hashimoto's thyroiditis"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-1521","authenticated-orcid":false,"given":"Yang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking 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