{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:24:54Z","timestamp":1787502294831,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,22]],"date-time":"2018-04-22T00:00:00Z","timestamp":1524355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Bimagrumab is a human monoclonal antibody inhibitor of activin type\n II<\/jats:styled-content>\n receptors (Act\n RII<\/jats:styled-content>\n ), with anabolic action on skeletal muscle mass by blocking binding of myostatin and other negative regulators of muscle growth. Bimagrumab is under evaluation for muscle wasting and associated functional loss in hip fracture and sarcopenia, and in obesity. Bimagrumab also blocks other endogenous Act\n RII<\/jats:styled-content>\n ligands, such as activins, which act on the neurohormonal axes, pituitary, gonads and adrenal glands.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To evaluate the effect of bimagrumab on the pituitary\u2010gonadal and pituitary\u2010adrenal axes in humans.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Healthy men and women, aged 55 to 75\u00a0years, received bimagrumab intravenously 10\u00a0mg\/kg or placebo on Day 1 and Day 29. Pituitary\u2010gonadal and pituitary\u2010adrenal functions were evaluated with basal hormone measurement and standard gonadotropin\u2010releasing hormone (Gn\n RH<\/jats:styled-content>\n ) and adrenocorticotropic hormone (\n ACTH<\/jats:styled-content>\n ) stimulation tests at baseline, Week 8 and at the end of study (\n EOS<\/jats:styled-content>\n )\u2014Week 20.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At Week 8, follicle\u2010stimulating hormone (\n FSH<\/jats:styled-content>\n ) levels were reduced by 42.16\n IU<\/jats:styled-content>\n \/L (\n P<\/jats:italic>\n \u00a0<\u00a0.001) and luteinizing hormone (\n LH<\/jats:styled-content>\n ) levels were increased by 2.5\n IU<\/jats:styled-content>\n \/L (\n P<\/jats:italic>\n \u00a0=\u00a0.08) over placebo in response to bimagrumab in women but not in men. Effects that were reversible after bimagrumab was cleared. Gonadal and adrenal androgen levels were not affected by exposure to bimagrumab.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Bimagrumab alters the function of pituitary gonadotroph cells, consistent with blockade of activin on local Act\n RII<\/jats:styled-content>\n . This effect is reversible with clearance of bimagrumab. Bimagrumab did not impact gonadal and adrenal androgen secretion.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13601","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T18:39:41Z","timestamp":1521743981000},"page":"908-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of bimagrumab, an activin receptor type\n II<\/scp>\n inhibitor, on pituitary neurohormonal axes"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-5267","authenticated-orcid":false,"given":"Tania","family":"Garito","sequence":"first","affiliation":[{"name":"San Raffaele Diabetes Research Institute Milan Italy"},{"name":"Novartis Institutes for BioMedical Research Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical 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