{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:39Z","timestamp":1740126099937,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["M01\u2010RR00425"],"award-info":[{"award-number":["M01\u2010RR00425"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01\u2010HL088457"],"award-info":[{"award-number":["R01\u2010HL088457"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30\u2010DK063491","R01\u2010DK079888"],"award-info":[{"award-number":["P30\u2010DK063491","R01\u2010DK079888"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Patients with type 2 diabetes mellitus have an increased risk of fracture despite normal or increased bone mineral density (BMD<\/jats:styled-content>). Studies on the relationship of glucose homeostasis with BMD<\/jats:styled-content> phenotypes have been inconclusive because distinguishing the roles of insulin resistance and hyperglycaemia in bone remodelling is challenging. In this study, we sought to define the relationship of site\u2010specific BMD<\/jats:styled-content> with glucose homeostasis traits and anthropometric traits.<\/jats:p><\/jats:sec>Design\/Patients\/Measurements<\/jats:title>In a cross\u2010sectional study, we examined 787 subjects from the Mexican\u2010American Coronary Artery Disease (MACAD<\/jats:styled-content>) cohort who had undergone euglycaemic\u2010hyperinsulinaemic clamps, oral glucose tolerance testing and dual X\u2010ray absorptiometry. Glucose homeostasis traits included insulinogenic index (IGI<\/jats:styled-content>30), insulin sensitivity (M value), insulin clearance (MCRI<\/jats:styled-content>), fasting insulin, fasting glucose and 2\u2010hour glucose. Univariate and multivariate analyses were performed to assess the association of glucose homeostasis and anthropometric traits with site\u2010specific BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Two\u2010hour glucose was negatively associated with arm BMD<\/jats:styled-content> in women, which remained significant in multivariate analysis (\u03b2\u00a0=\u00a0\u2212.15, P<\/jats:italic>\u00a0=\u00a0.0015). Positive correlations between fasting insulin and BMD<\/jats:styled-content> at weight\u2010bearing sites, including pelvis (\u03b2\u00a0=\u00a0.22, P<\/jats:italic>\u00a0<\u00a0.0001) and legs (\u03b2\u00a0=\u00a0.17, P<\/jats:italic>\u00a0=\u00a0.001) in women and pelvis (\u03b2\u00a0=\u00a0.33, P<\/jats:italic>\u00a0<\u00a0.0001) in men, lost significance after multivariate adjustment. Lean mass exhibited strong independent positive associations with BMD<\/jats:styled-content> at multiple sites in both sexes.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings suggest that (i) anabolic effects of insulin might work via mechanical loading from lean mass; (ii) a direct negative effect of increasing glucose might be more prominent at cortical\u2010bone\u2010rich sites in women; and (iii) lean mass is a strong positive predictor of bone mass.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13602","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T18:51:32Z","timestamp":1522003892000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between site\u2010specific bone mineral density and glucose homeostasis and anthropometric traits in healthy men and women"],"prefix":"10.1111","volume":"88","author":[{"given":"Se\u2010Min","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinrui","family":"Cui","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Rhyu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute for Translational Genomics and Population Sciences Los Angeles 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