{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:08:43Z","timestamp":1790752123643,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Appel d'offre interne (AOI) CHRU Montpellier","award":["UF 8751"],"award-info":[{"award-number":["UF 8751"]}]},{"name":"Appel d'offre interne (AOI) CHRU Montpellier","award":["UF 8854"],"award-info":[{"award-number":["UF 8854"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n This study compared the profiles of the two types of anorexia nervosa (\n AN<\/jats:styled-content>\n ; restrictive:\n AN<\/jats:styled-content>\n \u2010R, and binge eating\/purging:\n AN<\/jats:styled-content>\n \u2010\n BP<\/jats:styled-content>\n ) in terms of body composition, gynaecological status, disease history and the potential effects on bone metabolism.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Two hundred and eighty\u2010six women with\n AN<\/jats:styled-content>\n (21.8\u00a0\u00b1\u00a06.5\u00a0years; 204\n AN<\/jats:styled-content>\n \u2010R and 82\n AN<\/jats:styled-content>\n \u2010\n BP<\/jats:styled-content>\n ) and 130 age\u2010matched controls (\n CON<\/jats:styled-content>\n ; 22.6\u00a0\u00b1\u00a06.8\u00a0years) were enrolled. Areal bone mineral density (\n aBMD<\/jats:styled-content>\n ) was determined using\n DXA<\/jats:styled-content>\n and resting energy expenditure (\n REE<\/jats:styled-content>\n ) was indirectly assessed using calorimetry. Markers of bone formation (osteocalcin [\n OC<\/jats:styled-content>\n ], procollagen type I N\u2010terminal propeptide [\n PINP<\/jats:styled-content>\n ] and resorption (type I\u2010C telopeptide breakdown products [\n CTX<\/jats:styled-content>\n ]) and leptin were concomitantly evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Anorexia nervosa patients presented an alteration in\n aBMD<\/jats:styled-content>\n and bone turnover. When compared according to type,\n AN<\/jats:styled-content>\n \u2010\n BP<\/jats:styled-content>\n were older than\n AN<\/jats:styled-content>\n \u2010R and showed less severe undernutrition, lower\n CT<\/jats:styled-content>\n x levels, longer duration of\n AN<\/jats:styled-content>\n , and higher\n REE<\/jats:styled-content>\n levels and\n aBMD<\/jats:styled-content>\n at radius and lumbar spine. After adjustment for age, weight and hormonal contraceptive use, the\n aBMD<\/jats:styled-content>\n and\n CT<\/jats:styled-content>\n x differences disappeared. In both\n AN<\/jats:styled-content>\n groups,\n aBMD<\/jats:styled-content>\n was positively correlated with anthropometric parameters and negatively correlated with durations of\n AN<\/jats:styled-content>\n and amenorrhoea, the bone formation markers (\n OC<\/jats:styled-content>\n and\n PINP<\/jats:styled-content>\n ) and the leptin\/fat mass ratio.\n REE<\/jats:styled-content>\n was positively correlated with\n aBMD<\/jats:styled-content>\n in\n AN<\/jats:styled-content>\n \u2010R patients only.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study shows the profiles of\n AN<\/jats:styled-content>\n patients according to\n AN<\/jats:styled-content>\n type. However, the impact of the profile characteristics on bone status, although significant, was minor and disappeared after multiple adjustments. The positive correlation between\n REE<\/jats:styled-content>\n and\n aBMD<\/jats:styled-content>\n reinforces the concept that energy disposal and bone metabolism are strongly interdependent.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13610","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T02:40:02Z","timestamp":1523328002000},"page":"863-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of the two types of anorexia nervosa (binge eating\/purging and restrictive) on bone metabolism in female patients"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-1048","authenticated-orcid":false,"given":"Laurent","family":"Ma\u00efmoun","sequence":"first","affiliation":[{"name":"PhyMedExp Universit\u00e9 de Montpellier INSERM CNRS Montpellier France"},{"name":"D\u00e9partement de Biophysique Service de M\u00e9decine Nucl\u00e9aire 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