{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:46:11Z","timestamp":1793159171328,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyrotoxicosis, most often caused by Graves\u2019 disease (<jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content>), when treated inadequately may result in premature mortality. There is little consensus as to which of the 3 treatment options available \u2010 antithyroid drugs (<jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>), radioactive iodine (<jats:styled-content style=\"fixed-case\">RAI<\/jats:styled-content>) and surgery, is better.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>(i) To assess factors involved in treatment choice and treatment satisfaction in patients treated for Graves\u2019 disease; (ii) To assess quality of life (QoL) following treatment of Graves\u2019 disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants were selected from a prospective study cohort assessing thyrotoxicosis incidence and severity. Of the 172 eligible patients with Graves\u2019 disease, 123 treated patients participated (64% had received <jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content> only, 11% <jats:styled-content style=\"fixed-case\">RAI<\/jats:styled-content> and 25% total thyroidectomy, the latter 2 usually after a period of <jats:styled-content style=\"fixed-case\">ATD<\/jats:styled-content>), along with 18 untreated patients with newly diagnosed Graves\u2019 disease (overall participation rate, 73%). Consented patients completed a questionnaire detailing factors involved in treatment choice, QoL and satisfaction with treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants reported that the most important factors in choosing a treatment were the following: the effects on activities of daily living, concern about use of radioiodine, possibility of depression or anxiety, and doctor's recommendations. Satisfaction levels were high across all 3 treatment types. QoL 1\u2010year following treatment was higher than in untreated patients, and comparable with other international studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient satisfaction with therapy and QoL does not differ by treatment type. Therefore, clinical and social factors, in combination with patient choice and resource availability, should determine which treatment modality patients with Graves\u2019 disease should receive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13611","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T06:39:39Z","timestamp":1523342379000},"page":"977-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Treatment choice, satisfaction and quality of life in patients with Graves\u2019 disease"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-8426","authenticated-orcid":false,"given":"Helen M.","family":"Conaglen","sequence":"first","affiliation":[{"name":"Department of Medicine Faculty of Medical &amp; Health Sciences University of Auckland Waikato Clinical Campus  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade A. U.","family":"Tamatea","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medical &amp; Health Sciences University of Auckland Waikato Clinical Campus  Hamilton New Zealand"},{"name":"Department of Endocrinology Waikato Hospital  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Conaglen","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medical &amp; Health Sciences University of Auckland Waikato Clinical Campus  Hamilton New Zealand"},{"name":"Department of Endocrinology Waikato Hospital  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-2300","authenticated-orcid":false,"given":"Marianne S.","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medical &amp; Health Sciences University of Auckland Waikato Clinical Campus  Hamilton New Zealand"},{"name":"Department of Endocrinology Waikato Hospital  Hamilton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/B978-0-323-29738-7.00012-5","volume-title":"Williams textbook of endocrinology","author":"Davies TF","year":"2016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0500"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12688"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03097.x"},{"key":"e_1_2_6_6_1","first-page":"10","article-title":"The management of Graves\u2019 disease in New Zealand","volume":"129","author":"Cox S","year":"2016","journal-title":"N Z Med J"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00554.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2012.06233.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339473"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02336"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.06.193"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1322"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0798-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0462-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.03.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2133-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.07.061"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2015-133756"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1613-z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2006.00091.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.653"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9460-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-014-0126-z"},{"key":"e_1_2_6_25_1","first-page":"28","article-title":"Construct validity of the ThyPRO assessed by multiple groups confirmatory factor analysis in patients with thyroid diseases","volume":"19","author":"Watt T","year":"2010","journal-title":"Qual Life Res"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0521"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0433"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0044"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.1279"},{"key":"e_1_2_6_30_1","first-page":"85","article-title":"Treatment choice and satisfaction in thyrotoxicosis","volume":"130","author":"Conaglen HM","year":"2017","journal-title":"N Z Med J"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7863867"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365211"},{"key":"e_1_2_6_33_1","unstructured":"Ministry for culture and heritage. (1987)\u2018New Zealand goes nuclear\u2010free\u2019. New Zealand History updated 21\u2010Dec\u20102016.https:\/\/nzhistory.govt.nz\/new-zealand-becomes-nuclear-free."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.085720"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-68"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:20:09Z","timestamp":1695504009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/cen.13611"],"URL":"https:\/\/doi.org\/10.1111\/cen.13611","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"2017-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}