{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:41Z","timestamp":1787014001793,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["G11P 5662"],"award-info":[{"award-number":["G11P 5662"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["279408"],"award-info":[{"award-number":["279408"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["379600"],"award-info":[{"award-number":["379600"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["403963"],"award-info":[{"award-number":["403963"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["513823"],"award-info":[{"award-number":["513823"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["634492"],"award-info":[{"award-number":["634492"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1045710"],"award-info":[{"award-number":["1045710"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1060557"],"award-info":[{"award-number":["1060557"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Overt thyroid dysfunction is a risk factor for osteoporosis and fractures. Subclinical hyperthyroidism has also been associated with fracture. It remains unclear whether variation in thyroid hormones within the euthyroid range modulates bone health, particularly among older men. We assessed whether thyroid stimulating hormone (\n TSH<\/jats:styled-content>\n ) and free thyroxine (\n FT<\/jats:styled-content>\n 4) are associated with bone turnover markers (\n BTM<\/jats:styled-content>\n s) and predict hip fracture risk in community\u2010dwelling older men without known thyroid disease.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n Four thousand two hundred forty\u2010eight men aged 70\u201089\u00a0years.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Baseline blood samples were assayed for\n TSH<\/jats:styled-content>\n ,\n FT<\/jats:styled-content>\n 4, total osteocalcin (\n TOC<\/jats:styled-content>\n ), undercarboxylated osteocalcin (uc\n OC<\/jats:styled-content>\n ), N\u2010terminal propeptide of type I collagen (P1\n NP<\/jats:styled-content>\n ) and collagen type I C\u2010terminal cross\u2010linked telopeptide (\n CTX<\/jats:styled-content>\n ). Incidence of hip fracture events was ascertained to 2012. Associations of\n TSH<\/jats:styled-content>\n and\n FT<\/jats:styled-content>\n 4 with\n BTM<\/jats:styled-content>\n s were analysed at baseline using Pearson correlation coefficients, and with incident hip fracture using Cox proportional hazards regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After excluding men with pre\u2010existing thyroid or bone disease, there were 3, 338 men for analysis. Of these, 3, 117 were euthyroid, 135 had subclinical hypothyroidism, and 86 had subclinical hyperthyroidism. Men with subclinical thyroid disease were older, and those with subclinical hyperthyroidism had lower creatinine than the other groups. After multivariate analysis, there were no associations found between\n FT<\/jats:styled-content>\n 4,\n TSH<\/jats:styled-content>\n or subclinical thyroid dysfunction and\n BTM<\/jats:styled-content>\n s at baseline. Neither subclinical thyroid dysfunction,\n TSH<\/jats:styled-content>\n nor\n FT<\/jats:styled-content>\n 4 were predictive of incident hip fracture in our study population.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In euthyroid older men,\n TSH<\/jats:styled-content>\n and\n FT<\/jats:styled-content>\n 4 were not associated with\n BTM<\/jats:styled-content>\n s or incident hip fracture. Our findings differ from those previously described in postmenopausal women.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13615","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T18:29:37Z","timestamp":1523730577000},"page":"93-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Subclinical thyroid dysfunction and circulating thyroid hormones are not associated with bone turnover markers or incident hip fracture in older men"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9752-1413","authenticated-orcid":false,"given":"Ranita","family":"Siru","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Fiona Stanley Hospital Perth WA Australia"},{"name":"School of Medicine University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helman","family":"Alfonso","sequence":"additional","affiliation":[{"name":"School of Public Health Curtin University Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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Paul","family":"Chubb","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine Fiona Stanley Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"Queensland Research Centre for Peripheral Vascular Disease College of Medicine and Dentistry James Cook University Townsville QLD Australia"},{"name":"Department of Vascular and Endovascular Surgery The Townsville Hospital Townsville QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"School of Medicine University of Western Australia Perth WA Australia"},{"name":"Western Australian Centre for Health & Ageing University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-5892","authenticated-orcid":false,"given":"Bu 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