{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:30:04Z","timestamp":1789695004146,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Rathke's cleft cyst (<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) is a common sellar lesion which may cause visual impairment, hypopituitarism and headaches from mass effect. The natural history of these lesions is currently unclear. We investigated the natural history of <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>s and compared surgically treated patients with those treated conservatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of patients diagnosed with a <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> between 1996 and 2016 at Stanford University and Ospedale Maggiore Policlinico di Milano.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were divided into 2 cohorts: Group A, 72 subjects who underwent surgical resection of a symptomatic <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>, and Group B, 62 subjects managed conservatively. Compared to Group B, Group A subjects had larger <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>s (79% vs 22% had a largest diameter &gt;10\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and were more likely (41.5% vs 16%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) to present with hypopituitarism and diabetes insipidus (<jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content>) (18% vs 1.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). In Group A, after a mean follow\u2010up of 53.7\u00a0months, 12.5% of patients had recurrence and a second surgery. After surgery, 35% of patients recovered pituitary function. Hyperprolactinemia (26.6%) and hypogonadism (66.6%) resolved more commonly that did <jats:styled-content style=\"fixed-case\">DI<\/jats:styled-content> (20.1%). New pituitary deficits appeared in 16.6% of patients after surgery. In Group B, with a mean follow\u2010up of 41\u00a0months, only 6.4% had cyst enlargement, none underwent surgery, and none developed a pituitary deficit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data offer guidance in decision\u2010making regarding the management of <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> patients and confirm the safety of conservative treatment in asymptomatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13744","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T11:46:16Z","timestamp":1526903176000},"page":"178-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Natural history of Rathke's cleft cysts: A retrospective analysis of a two centres experience"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-9293","authenticated-orcid":false,"given":"Elisa","family":"Sala","sequence":"first","affiliation":[{"name":"Endocrinology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Department of Clinical Sciences and Community Health University of Milan  Milan Italy"},{"name":"Department of Neurological Surgery Stanford University Hospital  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stanford University Hospital  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Amorin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stanford University Hospital  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Carosi","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Hector","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stanford University Hospital  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffith R.","family":"Harsh","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stanford University Hospital  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Arosio","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Department of Clinical Sciences and Community Health University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Katznelson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stanford University Hospital  Stanford CA USA"},{"name":"Department of Medicine Stanford University Hospital  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.10.3455"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.1.8090885"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.6.1018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2604"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02446.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(01)00121-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.100.1.0033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.2.0189"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.04.023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8509"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490123"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01794.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.11.3972"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(91)90178-C"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000341873.20737.56"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.JNS09348"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.7.JNS091793"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2004.06.014"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.2.0209"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.4.0577"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003132"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.JNS091070"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K07E-070"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050699"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(99)90018-8"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:57:07Z","timestamp":1695002227000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/cen.13744"],"URL":"https:\/\/doi.org\/10.1111\/cen.13744","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,12]]},"assertion":[{"value":"2018-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}