{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:06:23Z","timestamp":1792551983021,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Liver cirrhosis (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>) was associated with an increased risk of osteoporosis; however, the association between <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and fracture risk was inconclusive. Therefore, this systematic review and meta\u2010analysis aims to explore the association between <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and fracture risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>To identify related literature, a systematic search of PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, Web of science and the Cochrane Library from 1965 to July 2017 without language limitation was performed. The random\u2010effects model described by DerSimonian and Laird was used to calculate pooled odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eventually, 5 cohort and 3 case\u2010control studies were identified, which included 321\u00a0035 subjects and 31\u00a0272 fracture cases. The pooled <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> of the association between <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and any fracture risk, hip fracture, spine\/trunk fracture and limb fracture was 1.94 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.59\u20102.37), 2.11 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.34\u20103.32), 2.00 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.50\u20102.67) and 1.82 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.65\u20102.01), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, this study indicates that cirrhotic patients have an increased risk of fracture. Preventive measures should be instituted as early as possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13762","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T13:44:12Z","timestamp":1528551852000},"page":"408-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The association between liver cirrhosis and fracture risk: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"89","author":[{"given":"Jie","family":"Liang","sequence":"first","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Dong","family":"Meng","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Long","family":"Li","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010Na","family":"Zhong","sequence":"additional","affiliation":[{"name":"Changde Third People's Hospital of Hunan  Changde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan\u2010Xuan","family":"Hou","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ying","family":"Long","sequence":"additional","affiliation":[{"name":"Shaoyang Maternal and Child Health Care Hospital of Hunan  Shaoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang\u2010Xiao","family":"Bao","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-6745","authenticated-orcid":false,"given":"Ming","family":"Bao","sequence":"additional","affiliation":[{"name":"Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12780"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.11.035"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0833-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02089.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt093"},{"key":"e_1_2_8_10_1","unstructured":"WellsGA SheaB O'ConnellD et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017342"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.82"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.04.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.001"},{"key":"e_1_2_8_17_1","first-page":"441","article-title":"Epidemiologic study of osteoporotic vertebral compression fractures in patients with chronic hepatitis B","volume":"34","author":"Zhang Q","year":"2013","journal-title":"J Cervicodynia Lumbodynia"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0077"},{"key":"e_1_2_8_19_1","first-page":"1397","article-title":"Osteoporosis in patients with primary biliary cirrhosis","volume":"22","author":"Wariaghli G","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280315"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0961-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.01.036"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.413"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3955-x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01464758"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:09:27Z","timestamp":1695002967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/cen.13762"],"URL":"https:\/\/doi.org\/10.1111\/cen.13762","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]},"assertion":[{"value":"2018-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}