{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:34:43Z","timestamp":1780965283562,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Discontinuation of dopamine agonist (<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long\u2010term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Patients<\/jats:title><jats:p>Retrospective cohort study of women with prolactinoma diagnosed before menopause and who after menopause were not on <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty women were included. Twenty\u2010eight received <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> (median duration 18\u00a0years, median age at <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> withdrawal 52\u00a0years). At last assessment (median follow\u2010up 3\u00a0years) and compared with values 6\u201012\u00a0months after stopping <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>, Prolactin (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>) increased in 15%, decreased but not normalized in 33% and was normal in 52%; <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> levels or visible adenoma on imaging before <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> withdrawal, treatment duration and presence of macro\u2010\/microadenoma at diagnosis were not predictors of normoprolactinaemia at last review, whereas <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> values 6\u201012\u00a0months after stopping <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> were. Adenoma regrowth was detected in 2\/27 patients (7%), who showed gradual increase in <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>. Comparison with 28 women who had <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> withdrawal before their menopause revealed lower risk of hyperprolactinaemia recurrence in the postmenopausal group (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>:0.316, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.101\u20100.985, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Two women with microprolactinoma diagnosed in perimenopausal period had not been offered <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> PRL<\/jats:styled-content> decreased (but not normalized) during observation of 1 and 8\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prolactin normalized over time in nearly half of the women and serum <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> 6\u201012\u00a0months after <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content> withdrawal is useful predictor. Nonetheless, 7% of the patients demonstrated adenoma regrowth which, given the life expectancy postmenopause, necessitate regular monitoring of the cases with persistent hyperprolactinaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13765","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T15:24:51Z","timestamp":1528817091000},"page":"346-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal"],"prefix":"10.1111","volume":"89","author":[{"given":"Sandhya","family":"Santharam","sequence":"first","affiliation":[{"name":"Institute of Metabolism and Systems Research (IMSR) College of Medical and Dental Sciences University of Birmingham  Birmingham UK"},{"name":"Centre for Endocrinology, Diabetes and Metabolism Birmingham Health Partners  Birmingham UK"},{"name":"Department of Endocrinology Queen Elizabeth Hospital University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Fountas","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research (IMSR) College of Medical and Dental Sciences University of Birmingham  Birmingham UK"},{"name":"Centre for Endocrinology, Diabetes and Metabolism Birmingham Health Partners  Birmingham UK"},{"name":"Department of Endocrinology Queen Elizabeth Hospital University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metaxia","family":"Tampourlou","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research (IMSR) College of Medical and Dental Sciences University of Birmingham  Birmingham UK"},{"name":"Centre for Endocrinology, Diabetes and Metabolism Birmingham Health Partners  Birmingham 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