{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:13:22Z","timestamp":1782407602397,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007671","name":"Fundaci\u00f3n para la Investigaci\u00f3n y la Prevenci\u00f3n del Sida en Espa\u00f1a","doi-asserted-by":"publisher","award":["FIPSE 24640\/07"],"award-info":[{"award-number":["FIPSE 24640\/07"]}],"id":[{"id":"10.13039\/501100007671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI070430"],"award-info":[{"award-number":["FIS PI070430"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>HIV<\/jats:styled-content> infection is associated with an increased risk of cardiovascular disease. Irisin is a miokyne secreted by skeletal muscle, which may influence insulin homeostasis, nonalcoholic fatty liver disease (NAFLD<\/jats:styled-content>) and atherosclerosis. Our objective was to evaluate the relationships between serum irisin, insulin homeostasis, NAFLD<\/jats:styled-content> and subclinical atherosclerosis in HIV<\/jats:styled-content>\u2010infected males.<\/jats:p><\/jats:sec>Design<\/jats:title>Cross\u2010sectional study in a cohort of HIV<\/jats:styled-content>\u2010infected patients.<\/jats:p><\/jats:sec>Patients<\/jats:title>Inclusion criteria: men older than 18\u00a0years; antiretroviral therapy (ART<\/jats:styled-content>) \u2010na\u00efve or on effective ART<\/jats:styled-content> (<50 HIV<\/jats:styled-content>\u20101 RNA<\/jats:styled-content>\u00a0copies\/mL<\/jats:styled-content>) without changes in the previous 6\u00a0months; no diabetes or hepatitis C.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Irisin was measured by enzymatic immunoassay (Phoenix Pharmaceuticals), insulin sensitivity by homeostasis model assessment of insulin resistance (HOMA<\/jats:styled-content>\u2010IR<\/jats:styled-content>), as well as the 2\u2010hour continuous infusion of glucose with model assessment (CIGMA<\/jats:styled-content>\u2010HOMA<\/jats:styled-content>). Hepatic steatosis was measured by 1\u2010H magnetic resonance spectroscopy, subclinical atherosclerosis by evaluation of carotid intima\u2010media thickness (C\u2010IMT<\/jats:styled-content>), measured by Ultrasonography.<\/jats:p><\/jats:sec>Results<\/jats:title>Eight nine men (age 42.0\u00a0\u00b1\u00a08.3\u00a0years, duration of HIV<\/jats:styled-content> infection 7.9\u00a0\u00b1\u00a05.6\u00a0years, CD<\/jats:styled-content>4 count 547\u00a0\u00b1\u00a0279\u00a0cells\/mL<\/jats:styled-content>) were included. Circulating irisin was positively related to HOMA<\/jats:styled-content>\u2010IR<\/jats:styled-content> and CIGMA<\/jats:styled-content>\u2010HOMA<\/jats:styled-content>, hepatic triglyceride content, and to VAT<\/jats:styled-content>\/SAT<\/jats:styled-content> ratio. Higher irisin concentrations were associated with higher C\u2010IMT<\/jats:styled-content>, although this association did not persist in multivariate analysis. Lipodystrophy and a higher baseline PAI<\/jats:styled-content>\u20101 concentration were independently associated with C\u2010IMT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In male HIV<\/jats:styled-content> patients without diabetes, higher irisin concentrations are positively associated with insulin resistance, NAFLD<\/jats:styled-content> and subclinical atherosclerosis. However, waist\u2010hip\u2010ratio is the main determinant of insulin resistance, and PAI<\/jats:styled-content>\u20101 and lipodystrophy were the strongest determinants of IMT<\/jats:styled-content> in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13800","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T06:49:32Z","timestamp":1530082172000},"page":"414-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High Irisin levels in nondiabetic HIV<\/scp>\u2010infected males are associated with insulin resistance, nonalcoholic fatty liver disease, and subclinical atherosclerosis"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-6404","authenticated-orcid":false,"given":"Oscar","family":"Moreno\u2010Perez","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Service University General Hospital of Alicante 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