{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:41Z","timestamp":1787014001905,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"2018 Hebei key research and development programme health care and biomedicine special project","award":["18277713D"],"award-info":[{"award-number":["18277713D"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Summary<\/jats:title>\n \n Introduction<\/jats:title>\n \n Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive\u2010age women. Irisin is considered to play a role in metabolic disorder and\n PCOS<\/jats:styled-content>\n . However, correlation between irisin and metabolic disorder in\n PCOS<\/jats:styled-content>\n is not clear.\n <\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n \n This is a prospective study. Forty patients with\n PCOS<\/jats:styled-content>\n and thirty patients without\n PCOS<\/jats:styled-content>\n were recruited for in vitro fertilization and embryo transfer (\n IVF<\/jats:styled-content>\n \u2010\n ET<\/jats:styled-content>\n ). All\n PCOS<\/jats:styled-content>\n women fulfilled all three Rotterdam consensus criteria. In each group, patients were also divided into obese and nonobese patients, and patients with or without dyslipidaemia.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Serum irisin level in\n PCOS<\/jats:styled-content>\n patients was significantly reduced. Irisin level in obese\n PCOS<\/jats:styled-content>\n patients was significantly lower than in nonobese\n PCOS<\/jats:styled-content>\n patients. Irisin level in\n PCOS<\/jats:styled-content>\n patients with dyslipidaemia was significantly higher than in\n PCOS<\/jats:styled-content>\n patients with normal blood lipid profile. In both\n PCOS<\/jats:styled-content>\n and control patients, serum irisin level was negatively correlated with body weight and waist\u2010hip ratio (\n WHR<\/jats:styled-content>\n ). Moreover, serum irisin level was positively correlated with body fat rate,\n BAI<\/jats:styled-content>\n , fasting plasma glucose (\n FPG<\/jats:styled-content>\n ) and\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n in\n PCOS<\/jats:styled-content>\n patients. In addition, serum irisin level was positively correlated with\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n in control patients. In\n PCOS<\/jats:styled-content>\n patients, body weight and\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n could predict the level of irisin. In control patients, body mass index (\n BMI<\/jats:styled-content>\n ) could predict the level of irisin. Expression of irisin in\n PCOS<\/jats:styled-content>\n patients was lower than that in control patients. However, there was no significant difference of irisin expression between the subdivided groups in\n PCOS<\/jats:styled-content>\n and control patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Taken together, the present findings enriched the knowledge about the role of irisin in metabolic dysfunction in\n PCOS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13805","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T14:33:41Z","timestamp":1530714821000},"page":"474-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Abnormal irisin level in serum and endometrium is associated with metabolic dysfunction in polycystic ovary syndrome 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