{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:29:10Z","timestamp":1788827350420,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T00:00:00Z","timestamp":1534636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Abnormal liver function tests (\n LFT<\/jats:styled-content>\n s) are frequent in Turner syndrome (\n TS<\/jats:styled-content>\n ). The causes and clinical significance are unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To investigate the prevalence of elevated\n LFT<\/jats:styled-content>\n s in adult\n TS<\/jats:styled-content>\n ; secondly, to analyse the associations between elevated\n LFT<\/jats:styled-content>\n s,\n TS<\/jats:styled-content>\n \u2010karyotypes and\n TS<\/jats:styled-content>\n \u2010related conditions; and thirdly, to evaluate liver stiffness and histological assessment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 125\n TS<\/jats:styled-content>\n women were retrospectively studied. Karyotypes, clinical and biochemical details and aortic measurements were recorded. Fibroscan and liver biopsy results were noted.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Elevated\n LFT<\/jats:styled-content>\n s were found in 49.6%: gamma\u2010glutamyltransferase (\n GGT<\/jats:styled-content>\n ) in 88.7%,\n ALK<\/jats:styled-content>\n in 45.2%,\n ALT<\/jats:styled-content>\n in 40.3% and\n AST<\/jats:styled-content>\n in 29%. A\n FIB<\/jats:styled-content>\n \u20104 index >1.3 was found in 11.8%. Women with isochromosome of the X long arm, iso[X](q), had a higher prevalence of elevated\n LFT<\/jats:styled-content>\n s. A lower prevalence of abnormal\n GGT<\/jats:styled-content>\n was found in patients with 45,X\/46,\n XX<\/jats:styled-content>\n , 45,X\/47,\n XXX<\/jats:styled-content>\n or 45,X\/46,\n XX<\/jats:styled-content>\n \/47,\n XXX<\/jats:styled-content>\n . Subjects with raised\n GGT<\/jats:styled-content>\n were older, shorter and more likely to have higher triglyceride levels. There was no association with\n HRT<\/jats:styled-content>\n duration after adjusting for age. Among patients with elevated aminotransferases, no differences were noted, except for higher\n HDL<\/jats:styled-content>\n \u2010cholesterol levels. The sinuses and ascending aorta diameter were greater in the elevated\n LFT<\/jats:styled-content>\n s group. Fibroscan was suggestive of significant liver fibrosis in 38.1%. Among 11 biopsies, liver architectural changes were reported in 45.4%, including two with cirrhosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Elevated\n LFT<\/jats:styled-content>\n s in\n TS<\/jats:styled-content>\n are common and important to detect given the possible progression towards severe liver disease. An association between raised\n LFT<\/jats:styled-content>\n s and karyotype iso[X]q was demonstrated. We have also shown a new association between abnormal\n LFT<\/jats:styled-content>\n s and aortic dilatation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.13811","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T23:22:55Z","timestamp":1531264975000},"page":"667-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Liver biochemical abnormalities in Turner syndrome: A comprehensive characterization of an adult population"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3913-9988","authenticated-orcid":false,"given":"Matilde","family":"Calanchini","sequence":"first","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology & Metabolism Churchill Hospital University of Oxford Oxford UK"},{"name":"Endocrinology & Metabolism Unit CTO A. Alesini Hospital ASL Roma 2 Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Moolla","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology & Metabolism Churchill Hospital University of Oxford Oxford UK"},{"name":"Oxford Centre for Diabetes, Endocrinology\u00a0& Metabolism Churchill Hospital National Institute for Health Research Oxford Biomedical Research Centre University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy W.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology\u00a0& Metabolism Churchill Hospital National Institute for Health Research Oxford Biomedical Research Centre University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy F.","family":"Cobbold","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Trust Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Grossman","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology & Metabolism Churchill Hospital University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Endocrinology & Metabolism Unit CTO A. 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