{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:43:45Z","timestamp":1774352625242,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Summary<\/jats:title>Context<\/jats:title>Although metabolic syndrome has been studied in patients with autonomous cortisol secretion, there are limited data for those with nonfunctioning adrenal incidentaloma (NFAI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess metabolic syndrome frequency in NFAI<\/jats:styled-content> patients and controls without adrenal adenoma according to World Health Organization (WHO<\/jats:styled-content>), National Cholesterol Education Program\u2010Adult Treatment Panel III<\/jats:styled-content> (NCEP<\/jats:styled-content>\u2010ATP III<\/jats:styled-content>), American Association of Clinical Endocrinologists\/American College of Endocrinology (AACE<\/jats:styled-content>\/ACE<\/jats:styled-content>) and International Diabetes Federation (IDF<\/jats:styled-content>) criteria.<\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective and transversal study.<\/jats:p><\/jats:sec>Patients<\/jats:title>Seventy\u2010four NFAI<\/jats:styled-content> and 90 controls were evaluated. NFAI<\/jats:styled-content> diagnosis was established according to current guidelines. The control group was selected based on normal adrenal imaging examinations.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Subjects were categorized by metabolic syndrome presence according to WHO<\/jats:styled-content>, NCEP<\/jats:styled-content>\u2010ATP III<\/jats:styled-content>, AACE<\/jats:styled-content>\/ACE<\/jats:styled-content> and IDF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Age, gender, ethnicity, body mass index, smoking, menopause, statin and fibrate use were comparable between patients and controls. The frequency of prediabetes, dyslipidaemia and hypertension as well as waist circumference were significantly higher in the NFAI<\/jats:styled-content> patients compared to the controls. The metabolic syndrome frequency in the NFAI<\/jats:styled-content> group was significantly higher compared to the normal adrenal group: WHO<\/jats:styled-content>: 69.2%\u00a0\u00d7<\/jats:italic>\u00a031.0% (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001); NCEP<\/jats:styled-content>\u2010ATP III<\/jats:styled-content>: 81.7%\u00a0\u00d7\u00a044.9% (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001); AACE<\/jats:styled-content>\/ACE<\/jats:styled-content>: 77.1%\u00a0\u00d7\u00a031.9% (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001); IDF<\/jats:styled-content>: 78.6%\u00a0\u00d7\u00a045.5% (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). Logistic regression analysis showed that NFAI<\/jats:styled-content> was a predictor of metabolic syndrome according to WHO<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001), NCEP<\/jats:styled-content>\u2010ATP III<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.005) and AACE<\/jats:styled-content>\/ACE<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.007).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Metabolic syndrome is frequently found in patients with NFAI<\/jats:styled-content>, and this frequency is higher in NFAI<\/jats:styled-content> patients than in those with normal adrenal imaging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13822","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T10:14:05Z","timestamp":1532513645000},"page":"586-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Nonfunctioning adrenal incidentaloma: A novel predictive factor for metabolic syndrome"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1003-6333","authenticated-orcid":false,"given":"Emanuela M.","family":"Ribeiro Cavalari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit Medical School and Hospital Universit\u00e1rio Clementino Fraga Filho Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela P.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit Medical School and Hospital Universit\u00e1rio Clementino Fraga Filho Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit Medical 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