{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:48:15Z","timestamp":1780480095322,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000862","name":"Sir Halley Stewart Trust","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Summary<\/jats:title>Objectives<\/jats:title>It is well established that UK<\/jats:styled-content> Asians typically have lower vitamin D levels than Caucasians. It is also known that vitamin D binding protein (DBP<\/jats:styled-content>) is lower in some races than Caucasians. To investigate how ethnicity, skin colour and genetic variation affect the response to vitamin D (15000\u00a0IU) administered to young Asian and Caucasian men.<\/jats:p><\/jats:sec>Design<\/jats:title>Prospective, single\u2010centre clinical trial.<\/jats:p><\/jats:sec>Participants<\/jats:title>Sixty young men (18\u201025\u00a0year) of Asian (n\u00a0=\u00a030) and Caucasian (n\u00a0=\u00a030) origin.<\/jats:p><\/jats:sec>Measurements<\/jats:title>We measured serum calcium, phosphate, magnesium, alkaline phosphatase, albumin, parathyroid hormone; total 25 hydroxyvitamin D (25OHD<\/jats:styled-content>); calculated and directly measured free 25OHD<\/jats:styled-content>; DBP<\/jats:styled-content> at baseline and 4\u00a0weeks; DBP<\/jats:styled-content> genotype, skin colour (Fitzpatrick scale), dietary vitamin D and calcium intake at baseline; and urine calcium:creatinine ratio at baseline, 1 and 4\u00a0weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>At baseline, Asians had lower serum total 25OHD<\/jats:styled-content> (26.4 [13.7] vs 34.1 [12.3] nmol\/L P<\/jats:italic>\u00a0=\u00a00.0272) and DBP<\/jats:styled-content> (6.7 [3.4] vs 9.6 [4.4] nmol\/L; P<\/jats:italic>\u00a0=\u00a00.0065) but similar free 25OHD<\/jats:styled-content> (16.7 [10.4] vs 17.8 [7.5] pmol\/L P<\/jats:italic>\u00a0=\u00a00.6530). After dosing, total 25OHD<\/jats:styled-content> rose similarly in each group (\u224856\u00a0nmol\/L), but measured free 25OHD<\/jats:styled-content> rose more in Asians (18.1 [9.4] vs 12.2 [13.3] pmol\/L P<\/jats:italic>\u00a0=\u00a00.0464). Lower DBP<\/jats:styled-content> at baseline, possibly reflecting genotype differences, was associated with a greater change in measured free 25OHD<\/jats:styled-content> in Caucasians, but not in Asians.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Asian compared with Caucasian males had a larger increment in measured free 25OHD<\/jats:styled-content> following 150\u00a0000 units vitamin D3, possibly reflecting differences in DBP<\/jats:styled-content> affinity for 25OHD<\/jats:styled-content>. Ethnicity should be considered when devising guidelines for the treatment of vitamin D deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13825","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T12:44:24Z","timestamp":1533300264000},"page":"222-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-3012","authenticated-orcid":false,"given":"Jaya Sujatha","family":"Gopal\u2010Kothandapani","sequence":"first","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy Faith","family":"Evans","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Gossiel","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Rigby","sequence":"additional","affiliation":[{"name":"Faculty of Health Hull York Medical School University of Hull Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"SACN vitamin D and health report \u2010 GOV.UK.Govuk.2017.https:\/\/www.gov.uk\/government\/publications\/sacn-vitamin-d-and-health-report. 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