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The Rotterdam Criteria were applied for <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> diagnosis. We used the homeostasis model assessment of insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> of \u03b2\u2010cell function (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010\u03b2) to evaluate insulin resistance and \u03b2\u2010cell dysfunction, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with non\u2010<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PCOS<\/jats:styled-content> showed a higher index of <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010\u03b2, and a higher prevalence of obesity, central obesity, and dyslipidaemia. High <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> was independently related to a high prevalence of obesity, central obesity, dyslipidaemia, and high blood glucose in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. In contrast, a low index of <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010\u03b2 index was independently correlated with a low prevalence of obesity, and central obesity, but negatively correlated with an elevated prevalence of high blood glucose in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. In addition, proportion of insulin resistance was higher than that of \u03b2\u2010cell dysfunction in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> with cardio\u2010metabolic disorders. \u03b2\u2010cell dysfunction was negatively correlated with the prevalence of central obesity and obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insulin resistance and \u03b2\u2010cell dysfunction independently affected cardio\u2010metabolic abnormalities in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, while insulin resistance was correlated with a higher prevalence of cardio\u2010metabolic abnormalities than that of \u03b2\u2010cell dysfunction. Moreover, \u03b2\u2010cell dysfunction and insulin resistance showed divergent correlations with obesity in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13832","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T10:04:37Z","timestamp":1534241077000},"page":"779-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insulin resistance and \u03b2\u2010cell dysfunction and the relationship with cardio\u2010metabolic disorders among women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-3825","authenticated-orcid":false,"given":"Liangshan","family":"Mu","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical 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Life Sciences Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-5579","authenticated-orcid":false,"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-1376","authenticated-orcid":false,"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology  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