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Owing to assumed superior absorption, calcium citrate is often recommended over calcium carbonate following <jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content> for the treatment of elevated <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>. We aimed to investigate the impact of either calcium carbonate or calcium citrate (1200\u00a0mg elementary calcium) in patients with elevated <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels following <jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Clinical, double\u2010blinded, randomized controlled trial of a 12\u2010week duration at a Danish University Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>Thirty\u2010nine (no drop out) <jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content> operated patients with elevated <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\u00a0&gt;\u00a06.9\u00a0pmol\/L) and normal plasma levels of calcium and 25\u2010hydroxyvitamin D were randomized to either calcium carbonate or calcium citrate (1200\u00a0mg elementary calcium\/daily). We assessed change in <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> as the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effect of the two calcium formulations on change in <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was comparable and neutral: \u22121.9% (calcium citrate) vs +0.9% (calcium carbonate), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.680. Compared to the carbonate\u2010treated group, the following bone turnover markers decreased significantly in the citrate\u2010treated group: procollagen I N\u2010terminal propeptide (\u221216.6% vs \u22123.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021), osteocalcin (\u221217.2% vs \u22124.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and bone\u2010specific alkaline phosphatase (\u22125.9% vs 3.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) and remained significantly decreased after multivariable adjustment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increasing the dose of calcium supplementation in <jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content> operated patients with slightly elevated <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels does not normalize <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels, regardless of the type of supplement. Our results do not support recommending supplementation with calcium citrate over calcium carbonate in <jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13836","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T22:04:53Z","timestamp":1534284293000},"page":"734-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of calcium citrate vs calcium carbonate on elevated parathyroid hormone after Roux\u2010en\u2010Y gastric bypass. 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