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We aimed to investigate the relationship between clinical and biochemical characteristics, and various domains of QoL in patients with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Measurements<\/jats:title><jats:p>We assessed the association between clinical and biochemical characteristics and QoL domains (psychosocial\u2013emotional, fertility, sexual function, and obesity\u2013menstrual) in a total of 211 women with PCOS using a specific health\u2010related quality\u2010of\u2010life questionnaire for PCOS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings showed positive significant association of QoL with age, and its negative significant associations with BMI, hirsutism and infertility (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). We also found a negative association between FAI and total QoL (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.14; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.042) and domains of hirsutism (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.14; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) and obesity\u2013menstrual (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.23; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). DHEAS was positively associated with the sexual function aspect of QoL (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.20; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). There were no significant associations between QoL and other hormonal parameters including LH to FSH ratio and total testosterone (tT). Significant associations were found between triglycerides (TG), total cholesterol (TC), LDL and HDL cholesterol, and domain of obesity\u2013menstrual of QoL. HOMA\u2010IR was significantly related to all QoL domains except self\u2010image and hirsutism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although biochemical markers can influence QoL in patients with PCOS, clinical manifestations of this syndrome such as obesity, infertility and hirsutism seem to play roles in worsening QoL, in particular for psychosocial domains. Hence, clinicians should regularly assess the clinical and psychosocial dimensions of PCOS as well as biochemical aspects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13858","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:11:24Z","timestamp":1537359084000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The relationship between clinical and biochemical characteristics and quality of life in patients with polycystic ovary syndrome"],"prefix":"10.1111","volume":"90","author":[{"given":"Mina","family":"Amiri","sequence":"first","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Bidhendi Yarandi","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Nahidi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Health and Midwifery, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tohidi","sequence":"additional","affiliation":[{"name":"Prevention of Metabolic Disorders Research Center Research Institute for Endocrine Sciences, Shahid Beheshti University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-065X","authenticated-orcid":false,"given":"Fahimeh","family":"Ramezani Tehrani","sequence":"additional","affiliation":[{"name":"Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.035"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041536"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00117-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884217504272945"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/13591053030083004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200405000-00011"},{"key":"e_1_2_8_11_1","article-title":"Psychological distress, anger and quality of life in polycystic ovary syndrome: associations with biochemical, phenotypical andsocio\u2010demographic factors","volume":"1","author":"Borghi L","year":"2017","journal-title":"J Psychosom Obstet Gynecol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.156.6.556"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162911"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123608"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0039"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.10.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","unstructured":"FraserIS CritchleyHO BroderM MunroMG.The FIGO recommendations on terminologies and definitions for normal and abnormal uterine bleeding. 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