{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:56:51Z","timestamp":1789772211720,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Impaired quality of life (QoL) in primary hyperparathyroidism (PHPT) is commonly present. Patients may complain about nonspecific neurocognitive symptoms which can be difficult to quantify. Two different disease\u2010specific questionnaires have been developed, that is, the parathyroid assessment of symptoms score (PAS) and the primary hyperparathyroidism quality of life (PHPQoL). Using these two questionnaires, we assessed relationship between QoL and biochemical indices in PHPT and effects of parathyroidectomy (PTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with PHPT diagnosed from 2015 to 2017 were asked to answer the questionnaires before and 12\u00a0months after PTX. Biochemistry was obtained on both occasions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 104 PHPT patients answered PAS and PHPQoL questionnaires at baseline, with a median age of 64\u00a0years (73% females). PHPQoL score correlated inversely with ionized calcium and PTH at baseline (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0\u02c2\u00a00.04). Total PAS and PHPQoL score did not differ between those with and without osteoporosis, renal calcifications and impaired renal function. Based on levels of ionized calcium, PHPQoL differed significantly between patients with mild\u2010 and moderate\u2010severe hypercalcemia (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). Fifty\u2010three patients answered PAS and PHPQoL 12\u00a0months after PTX showing an improved QoL at follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      \u00a0\u02c2\u00a00.02). Stratifying patients into groups based on levels of ionized calcium showed a significantly improved PHPQoL score in patients with mild (\u02c21.45\u00a0mmol\/L) as well as moderate\u2010severe hypercalcemia (\u22651.45\u00a0mmol\/L) at follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      \u00a0\u02c2\u00a00.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quality of life improved 12\u00a0months after PTX in PHPT patients. Impaired QoL seems to be associated with the degree of hypercalcemia rather than organ manifestations attributable to PHPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13865","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T09:42:55Z","timestamp":1538214175000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Health\u2010related quality of life improves 1\u00a0year after parathyroidectomy in primary hyperparathyroidism: A prospective cohort study"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-0713","authenticated-orcid":false,"given":"Henriette","family":"Ejlsmark\u2010Svensson","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus 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