{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:22:02Z","timestamp":1773796922065,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0500783"],"award-info":[{"award-number":["G0500783"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000884","name":"British Thyroid Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000382","name":"Society for Endocrinology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      B lymphocyte activating factor (BAFF), a member of the tumour necrosis factor superfamily, is essential for B cell activation, differentiation and survival. Elevated circulating BAFF levels have been found in patients with several autoimmune conditions, including Graves\u2019 disease. In addition,\n                      <jats:italic>BAFF<\/jats:italic>\n                      gene variants have been associated with Graves\u2019 disease in a Taiwanese cohort, and with several other autoimmune conditions in non\u2010Taiwanese populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods<\/jats:title>\n                    <jats:p>\n                      We performed a case\u2010control association study to investigate two\n                      <jats:italic>BAFF<\/jats:italic>\n                      polymorphisms (\n                      <jats:italic>rs9514828<\/jats:italic>\n                      and\n                      <jats:italic>rs4000607<\/jats:italic>\n                      ) in a UK cohort of 444 patients with Graves\u2019 disease. Genotype frequencies were compared to those from 447 local controls and more than 5000 healthy controls from the Wellcome Trust case\u2010control consortium (WTCCC2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant difference in the frequency of the AA genotype at\n                      <jats:italic>rs4000607<\/jats:italic>\n                      between the Graves\u2019 disease cohort and both the local controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.045) and the WTCCC2 controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a04.56\u00a0\u00d7\u00a010\n                      <jats:sup>\u22126<\/jats:sup>\n                      ). Furthermore, the frequency of the A allele was found to be increased in the Graves\u2019 disease group compared to WTCCC2 controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02, OR 1.20 (95% CI 1.03\u20101.41). No association was observed at the\n                      <jats:italic>rs9514828<\/jats:italic>\n                      locus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Dysfunction of the humoral immune system is an obligatory pathophysiological component of Graves\u2019 disease, hence\n                      <jats:italic>BAFF<\/jats:italic>\n                      is an excellent functional candidate gene. We have demonstrated, for the first time, a significant association of the\n                      <jats:italic>BAFF<\/jats:italic>\n                      polymorphism\n                      <jats:italic>rs4000607<\/jats:italic>\n                      with Graves\u2019 disease in a UK cohort. Further work to elucidate the role of BAFF in the pathogenesis of Graves\u2019 disease is now warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13872","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T12:14:08Z","timestamp":1538741648000},"page":"170-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Analysis of BAFF gene polymorphisms in UK Graves\u2019 disease patients"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-2701","authenticated-orcid":false,"given":"Laura C.","family":"Lane","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology The Great North Children\u2019s Hospital Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen R.","family":"Allinson","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Campbell","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishita","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Ingoe","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Endocrine Unit Royal Victoria Infirmary Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Razvi","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Cheetham","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology The Great North Children\u2019s Hospital Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J.","family":"Cordell","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon H.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Endocrine Unit Royal Victoria Infirmary Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Endocrine Unit Royal Victoria Infirmary Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1306-5"},{"issue":"25","key":"e_1_2_7_3_1","first-page":"719","article-title":"Familial studies of autoimmune thyroiditis","volume":"2","author":"Hall R","year":"1967","journal-title":"Clin. 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