{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:15:31Z","timestamp":1787170531320,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Radioiodine (RAI) is an effective treatment for Graves\u2019 thyrotoxicosis but is associated with a failure rate of 15% and may be a risk factor for thyroid eye disease (TED) and weight gain. We sought to examine predictors of RAI failure, weight gain, TED and patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>A total of 655 episodes of RAI in Graves\u2019 thyrotoxicosis patients (2006\u20102015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Biochemical assessment, including TFTs and thyrotropin receptor antibodies (TRAb), clinical features (eg, TED, weight and thionamide use) and patient questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The treatment failure rate was 17%. Failure was greater with higher fT4 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002) and higher TRAb (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004). Failure rate was 42.2% when TRAb &gt;40\u00a0U\/L. Median weight gain was 3.2\u00a0kg in those with normal fT4 prior to RAI and 5.8\u00a0kg when fT4 was elevated (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). New TED developed in 7.6% but was not associated with post\u2010RAI dysthyroidism. Treatment satisfaction was generally high (median response 8\/10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment failure after RAI occurs in predictable groups and this should be reflected in the information provided to patients. Weight gain is common and may not entirely be explained by a return to pre\u2010thyrotoxic baseline. We were unable to detect any significant impact of post\u2010RAI dysthyroidism on weight gain, TED or thyroid symptoms in this large cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13873","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T07:48:22Z","timestamp":1538812102000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Predicting outcomes and complications following radioiodine therapy in Graves\u2019 thyrotoxicosis"],"prefix":"10.1111","volume":"90","author":[{"given":"Ei Thuzar","family":"Aung","sequence":"first","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola N.","family":"Zammitt","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Dover","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W. J.","family":"Strachan","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Seckl","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes Royal Infirmary of Edinburgh Edinburgh UK"},{"name":"Centre for Cardiovascular Science, Queen\u2019s Medical Research Unit University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-6463","authenticated-orcid":false,"given":"Fraser W.","family":"Gibb","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes Royal Infirmary of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60782-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.2986"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03291.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01329.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1300494"},{"issue":"9","key":"e_1_2_6_7_1","first-page":"764","article-title":"Predictors of treatment failure, incipient hypothyroidism, and weight gain following radioiodine therapy for graves' thyrotoxicosis","volume":"36","author":"Gibb FW","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.8.3611"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.11.025"},{"key":"e_1_2_6_11_1","unstructured":"National Institutes of Health ClinicalTrials.gov.Post\u2010Radioiodine Graves' Management: The PRAGMA\u2010Study (PRAGMA);2017.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01885533. 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