{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:42:12Z","timestamp":1790656932846,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adrenal surgery remains a distinct surgical challenge. Technical challenges associated with laparoscopic adrenalectomy are tumour size, haemorrhage control and oncological compromise. Hand\u2010assisted laparoscopic (HAL) adrenalectomy, utilizing a hand\u2010port device, offers minimally invasive surgery with the advantages and safety of tactile feedback. We aimed to assess the efficacy of HAL for patients requiring adrenalectomy for tumours over 5\u00a0cm in size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>Hand\u2010assisted laparoscopic surgery is used in several surgical specialities over totally laparoscopic surgery to manage sizeable pathology, reduce operating time and conversion rates. HAL adrenalectomy is demonstrated in this series as a safe alternative to laparoscopic adrenalectomy for large adrenal tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective analysis of all HAL adrenalectomies performed over 8\u00a0years (October 2006\u2010May 2015) by a single surgeon was performed. This case series is the largest study of this technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>All patients who were fit for surgery with adrenal tumours (over 5\u00a0cm) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Analysis<\/jats:title><jats:p>Primary endpoints were overall mortality, operating time, hospital stay, complications and conversion to open surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 56 patients underwent the procedure. A total of 43 had unilateral and 13 bilateral lesions. Most lesions (45) were histologically benign. These included functioning and non\u2010functioning tumours. Median tumour size was 8\u00a0cm (range 5\u201019\u00a0cm). There was one (1.8%) intra\u2010operative conversion and no peri\u2010operative mortality. Postoperative complications occurred in 8 (14%) patients, all self\u2010limiting. The median length of stay was 6\u00a0days (range 2\u201021). There was one recurrence of pathology with repeat surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hand\u2010assisted laparoscopic surgery offers a safe reproducible approach to adrenal surgery combining minimally invasive surgery with tactile integration. Although previously described in small numbers, this represents the largest case series to date. HAL is a safe minimally invasive surgical option for larger tumours, including malignancies. The HAL technique may additionally offer a shorter learning curve for trainee adrenal surgeons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13883","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:53:01Z","timestamp":1540219981000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Laparoscopic hand\u2010assisted adrenalectomy for tumours larger than 5\u00a0cm"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-3377","authenticated-orcid":false,"given":"Jennifer","family":"Buxton","sequence":"first","affiliation":[{"name":"Departments of Transplant and Endocrine Surgery Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen H.","family":"Vun","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Endocrine Surgery Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"van Dellen","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Endocrine Surgery Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health University of Manchester, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wadsworth","sequence":"additional","affiliation":[{"name":"Departments of Anaesthetics Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Augustine","sequence":"additional","affiliation":[{"name":"Departments of Transplant and Endocrine Surgery Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester UK"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health University of Manchester, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre Manchester 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