{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:26:03Z","timestamp":1745407563498,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Literature concerning the impact of multiple endocrine neoplasia type 1 (MEN 1) on fertility is limited to case reports despite the early onset of endocrinopathies, such as primary hyperparathyroidism and prolactinoma, that may impact fertility. This study describes the impact of unrecognized and untreated MEN 1 on fertility and pregnancy outcomes in a multigenerational cohort of the Tasman 1 MEN 1 kindred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All <jats:italic>MEN 1<\/jats:italic> positive (<jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic>, n\u00a0=\u00a063) and <jats:italic>MEN 1<\/jats:italic> negative (<jats:italic>MEN 1<jats:sup>\u2212<\/jats:sup>,<\/jats:italic> n\u00a0=\u00a075) descendants born between 1825 and 1951 of a common founder. Review of birth, death, marriage and medical records provided data on date of birth and death, gender, MEN 1 status and the number of pregnancies and children per parent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to <jats:italic>MEN 1<jats:sup>\u2212<\/jats:sup><\/jats:italic> parents, <jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic> parents had more children (RR 1.30, 1.02\u20101.66) and live births (RR 1.31, 1.02\u20101.67) with no excess of stillbirths (RR 1.24, 0.24\u20106.36). Compared to the era\u2010matched Tasmanian fertility rate, <jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic> parents had more children (4.87\u00a0\u00b1\u00a04.11 vs 3.40\u00a0\u00b1\u00a00.61, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.048), whereas <jats:italic>MEN 1<jats:sup>\u2212<\/jats:sup><\/jats:italic> parents had similar numbers of children (3.67\u00a0\u00b1\u00a03.27 vs 3.36\u00a0\u00b1\u00a00.62, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.55). <jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic> parents had a similar number of <jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic> and <jats:italic>MEN 1<jats:sup>\u2212<\/jats:sup><\/jats:italic> offspring (2.1\u00a0\u00b1\u00a01.9 vs 2.5\u00a0\u00b1\u00a02.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.31). Indirectly assessed miscarriage rate was similar between <jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic> and <jats:italic>MEN 1<jats:sup>\u2212<\/jats:sup><\/jats:italic> mothers (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.77). Clinically overt pituitary disease reduced <jats:italic>MEN 1<jats:sup>+<\/jats:sup><\/jats:italic> kindred member likelihood of parenthood (33% vs 97%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no adverse impact of MEN 1 on patient fertility overall; however, MEN 1\u2010related pathology may have impaired the reproductive potential of a subset of individuals with pituitary disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13890","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T10:03:44Z","timestamp":1540721024000},"page":"312-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["No evidence of adverse fertility and pregnancy outcomes in patients with unrecognized and untreated multiple endocrine neoplasia type 1"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-5808","authenticated-orcid":false,"given":"Michael","family":"Thompson","sequence":"first","affiliation":[{"name":"School of Medicine, Department of Diabetes and Endocrinology, Royal Hobart Hospital University of Tasmania  Hobart Tasmania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Burgess","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Diabetes and Endocrinology, Royal Hobart Hospital University of Tasmania  Hobart Tasmania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1630"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-38"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0950"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00275.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1841"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3659"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0848"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.12.017"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03495.x"},{"key":"e_1_2_8_12_1","first-page":"1028","article-title":"Primary hyperparathyroidism during pregnancy","volume":"110","author":"Kelly TR","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_8_13_1","first-page":"217","article-title":"Management of a multiple endocrine neoplasia type 1 during pregnancy: a case report and review of the literature","volume":"11","author":"Daglar HK","year":"2016","journal-title":"J Exp Ther Oncol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X14532634"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0354-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.2.126"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.10.1119"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb133152.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410320017001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01615440.2013.847775"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2733841"},{"key":"e_1_2_8_22_1","unstructured":"Commonwealth of Australia.Census of the Commonwealth of Australia. 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