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We compared plasma (apo)lipoproteins and lipoprotein particle characteristics, GlycA, a pro\u2010inflammatory glycoprotein biomarker of enhanced chronic inflammation, and plasma total branched\u2010chain amino acids (BCAA), measured using nuclear magnetic resonance (NMR) spectroscopy, between patients with PA, control subjects without hypertension, subjects with untreated hypertension and subjects with treated hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty PA patients were individually matched with 2819 control subjects without hypertension, 501 subjects with untreated hypertension and 878 subjects with treated hypertension participating in the PREVEND (Prevention of Renal and Vascular End\u2010Stage Disease) cohort study with respect to age, sex, body mass index, smoking and statin use. The Vantera\u00ae Clinical Analyzer was used to determine NMR\u2010based laboratory parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total cholesterol, low\u2010density lipoprotein cholesterol (LDL\u2010C), high\u2010density lipoprotein cholesterol (HDL\u2010C), apolipoprotein (apo) B, apolipoprotein A\u2010I (apoA\u2010I), LDL particle and HDL particle concentrations were all decreased in PA subjects vs control subjects and subjects with untreated hypertension (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.016). Triglycerides (TG) and triglyceride\u2010rich lipoprotein (TRL) concentrations were lower in PA subjects vs subjects with (untreated) hypertension. GlycA was increased in PA vs the three comparator groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.016). Total BCAA concentrations were unaltered in PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary aldosteronism is associated with lower concentrations of LDL and HDL particles and to some extent also with lower TG and TRL particle concentrations. PA is also characterized by increased GlycA levels, indicating enhanced low\u2010grade chronic inflammation. Low HDL particle concentrations and increased GlycA could contribute to accelerated cardiovascular disease development in PA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13891","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T19:24:23Z","timestamp":1540841063000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Primary aldosteronism is associated with decreased low\u2010density and high\u2010density lipoprotein particle concentrations and increased GlycA, a pro\u2010inflammatory glycoprotein biomarker"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-332X","authenticated-orcid":false,"given":"Annika M. A.","family":"Berends","sequence":"first","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Buitenwerf","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eke G.","family":"Gruppen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Nephrology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J.","family":"Sluiter","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J. 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