{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:31:50Z","timestamp":1790415110168,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["2009-139"],"award-info":[{"award-number":["2009-139"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008017","name":"Institut Gustave-Roussy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2009-139"],"award-info":[{"award-number":["2009-139"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid cancers are threefold more frequent in women than in men. A role of reproductive or hormonal factors has been suggested but with contradictory results. We investigated potential associations between history of hysterectomy, with or without oophorectomy, and history of benign gynaecological disease (uterine fibroids, endometriosis) and the incidence of differentiated thyroid cancer, in a large French prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 89\u00a0340 women from the E3N cohort were followed up between 1990 and 2012. Gynaecological diseases treated by surgery were self\u2010reported. Thyroid cancers were validated by histological reports. Time\u2010dependent covariates included smoking status, BMI and history of benign thyroid disease. Cox proportional hazard models with age as timescale were used to estimate Hazard Ratios (HR) and 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 412 cases of thyroid cancer were diagnosed during follow\u2010up. A history of hysterectomy was associated with an increased risk of differentiated thyroid cancer (adjusted HR=2.05; 95%CI: 1.65\u20102.55). The association was not altered after further adjustment for reproductive factors. Endometriosis, uterine polyps, ovarian cysts and oophorectomy without hysterectomy were not associated with the risk of thyroid cancer. A history of fibroids was also significantly related to the risk of thyroid cancer over the follow\u2010up period (adjusted HR=1.91; 95%CI: 1.50\u20102.44) and the increased risk persisted after adjustment for history of hysterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women who had either a history of fibroids or hysterectomy had an increased risk of differentiated thyroid cancer. These findings suggest shared biological mechanisms between fibroids and thyroid cancer, which deserve to be further dissected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13899","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T10:14:33Z","timestamp":1541240073000},"page":"360-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relation between hysterectomy, oophorectomy and the risk of incident differentiated thyroid cancer: The E3N cohort"],"prefix":"10.1111","volume":"90","author":[{"given":"Agathe","family":"Guenego","sequence":"first","affiliation":[{"name":"Service d\u2019Endocrinologie CHU de Rennes Rennes France"},{"name":"Univ Rennes1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Mesrine","sequence":"additional","affiliation":[{"name":"Inserm U1018, CESP, Health Across Generations Team Universit\u00e9 Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"},{"name":"Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laureen","family":"Dartois","sequence":"additional","affiliation":[{"name":"Inserm U1018, CESP, Health Across Generations Team Universit\u00e9 Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"},{"name":"Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Leenhardt","sequence":"additional","affiliation":[{"name":"Thyroid and Endocrine Tumors Unit, Institut of Endocrinology Piti\u00e9 Salp\u00eatri\u00e8re Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Clavel\u2010Chapelon","sequence":"additional","affiliation":[{"name":"Inserm U1018, CESP, Health Across Generations Team Universit\u00e9 Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"},{"name":"Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kvaskoff","sequence":"additional","affiliation":[{"name":"Inserm U1018, CESP, Health Across Generations Team Universit\u00e9 Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"},{"name":"Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Boutron\u2010Ruault","sequence":"additional","affiliation":[{"name":"Inserm U1018, CESP, Health Across Generations Team Universit\u00e9 Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"},{"name":"Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-8228","authenticated-orcid":false,"given":"Fabrice","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie CHU de Rennes Rennes France"},{"name":"Univ Rennes1 Rennes France"},{"name":"Inserm U1018, CESP, Health Across Generations Team Universit\u00e9 Paris\u2010Saclay, University Paris\u2010Sud, UVSQ Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21195"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.04.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25066"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.04.020"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0546-z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-14-0053"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0084-x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29067"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3165-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.02.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0367"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00040"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/103515"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.121"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010276"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi136"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu184"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.3.476"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-005-0036-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008880429862"},{"issue":"11","key":"e_1_2_8_23_1","first-page":"991","article-title":"Reproductive and hormonal risk factors for thyroid cancer in Los Angeles County females","volume":"8","author":"Mack WJ","year":"1999","journal-title":"Cancer Epidemiol Biomarkers"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70550-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem209"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000164812.02181.d5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei462"},{"issue":"1","key":"e_1_2_8_28_1","first-page":"35","article-title":"Evaluation and management of abnormal uterine bleeding in premenopausal women","volume":"85","author":"Sweet MG","year":"2012","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0903"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299741"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0330"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-024"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.03.003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-383"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/864852"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000066800.44492.1B"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00053"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00124"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e318252e450"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0713"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/dmp.2011.21"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00314"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.13899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T20:45:55Z","timestamp":1694378755000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/cen.13899"],"URL":"https:\/\/doi.org\/10.1111\/cen.13899","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"2018-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}