{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:06:08Z","timestamp":1791533168173,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T00:00:00Z","timestamp":1544313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Data on longitudinal changes of computed tomography (CT)\u2010determined visceral fat area (VFA), skeletal muscle area (SMA) and skeletal muscle radiodensity (SMD) after adrenalectomy are limited in patients with hypercortisolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association of severity of cortisol excess and improvement of CT\u2010based muscle and fat parameters after adrenalectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>One hundred thirty\u2010four patients with overt Cushing's syndrome (CS; n\u00a0=\u00a039), mild autonomous cortisol excess (MACE; n\u00a0=\u00a057), or nonfunctioning adrenal tumour (NFAT; n\u00a0=\u00a038) at a tertiary endocrinology institution between 2006 and 2017 were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Changes in CT\u2010determined VFA, visceral\u2010to\u2010subcutaneous fat ratio (VSR), SMA, skeletal muscle index (SMI), and SMD measured at the third lumbar vertebra (L3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, CS patients had higher VFA, lower SMA, SMI and SMD values, compared to NFAT or MACE patients. Compared to NFAT, significant decreases in VFA and increases in SMA, SMI and SMD was observed in CS 1\u00a0year after adrenalectomy. In MACE, adjusted mean changes of SMD but not VFA, SMA or SMI differ significantly compared to NFAT (+8.9% vs \u22123.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.032). In a multivariate linear regression model, the increase by 1\u00a0\u03bcg\/dL of post\u2010dexamethasone serum cortisol at baseline was independently associated with greater reduction of VFA (\u22123.95%), VSR (\u22123.07%), and increase in SMD (+0.92%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 for all) after adrenalectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The severity of cortisol excess was associated with greater improvement of L3 VFA\n                      <jats:italic>,<\/jats:italic>\n                      VSR and SMD 1\u00a0year after adrenalectomy. These CT\u2010based markers may allow more objective assessment of treatment benefit at earlier stage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.13902","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T17:14:53Z","timestamp":1542215693000},"page":"267-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Changes of computed tomography\u2010based body composition after adrenalectomy in patients with endogenous hypercortisolism"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-1956","authenticated-orcid":false,"given":"Namki","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine Seoul 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