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Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. We present a practical, clinical approach to management of hypothalamic disease in a patient with craniopharyngioma and highlight potential targets for future pharmacological or surgical intervention.<\/jats:p>","DOI":"10.1111\/cen.13929","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T02:42:55Z","timestamp":1546828975000},"page":"506-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Management of hypothalamic disease in patients with craniopharyngioma"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-8999","authenticated-orcid":false,"given":"Christopher J.","family":"Thompson","sequence":"first","affiliation":[{"name":"Academic Department of Endocrinology Beaumont Hospital Dublin Ireland"},{"name":"Royal College of Surgeons in Ireland Beaumont Hospital Dublin 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