{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:28:59Z","timestamp":1790872139642,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK073632"],"award-info":[{"award-number":["R01-DK073632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HD29364"],"award-info":[{"award-number":["R01-HD29364"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine\u2010metabolic disorder associated with insulin resistance (IR). In IR states, non\u2013insulin\u2010mediated glucose uptake (NIMGU) may increase to compensate for declining insulin\u2010mediated glucose uptake (IMGU), although this does not appear to be the case in PCOS. The underlying molecular mechanisms for this deficiency remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare adipocyte glucose transporter 1 and 4 (GLUT\u20101 and GLUT\u20104) gene expression in PCOS women and matched controls, and to determine whether changes in GLUT\u20101 and GLUT\u20104 are associated with concomitant alterations in whole\u2010body glucose uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research design and methods<\/jats:title><jats:p>In this prospective cross\u2010sectional study, 23 women with PCOS (by NIH 1990 criteria) and 23 matched controls were studied for subcutaneous abdominal adipocyte GLUT\u20101 and GLUT\u20104 mRNA expression (by real\u2010time PCR), and basal whole\u2010body IR (by HOMA\u2010IR) and insulin secretion (by HOMA\u2010\u03b2%). A subset of six PCOS women and six matched controls also underwent a mFSIVGTT to determine dynamic state glucose uptake (by insulin sensitivity index [Si] and glucose effectiveness [Sg]) and insulin secretion (by the acute insulin response to glucose [AIRg] and the disposition index [Di]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For similar adiposity (BMI and waist\u2010hip ratio), PCOS women tended to have higher HOMA\u2010IR and lower Di and Si, and higher HOMA\u2010\u03b2% and lower GLUT\u20104 than controls, while GLUT\u20101 was similar. GLUT\u20101 was positively associated with Sg (reflecting NIMGU) and GLUT\u20104 positively with Si (reflecting IMGU). GLUT\u20104 was associated negatively with HOMA\u2010IR and HOMA\u2010\u03b2% and positively with Di for the entire cohort but not with AIRg. Both GLUT\u20101 and GLU\u20104 were negatively associated with BMI, but not with each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that IR secondary to a lower IMGU and enhanced insulin secretion in PCOS is in part attributable to a reduction in adipocyte GLUT\u20104 expression that is not accompanied by a compensatory increase in GLUT\u20101 expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13931","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T07:26:19Z","timestamp":1547018779000},"page":"542-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin\u2010mediated and non\u2013insulin\u2010mediated whole\u2010body glucose uptake"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-1473","authenticated-orcid":false,"given":"Uche","family":"Ezeh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Stanford Healthcare\u2010ValleyCare Hospital Pleasanton California"},{"name":"Department of Obstetrics &amp; Gynecology and Center for Androgen\u2010Related Disorders Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Department of Obstetrics &amp; Gynecology, Medical College of Georgia Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Y.\u2010D.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology and Center for Androgen\u2010Related Disorders Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Institute for Translational Genomics and Population Sciences Los Angeles Biomedical Research Institute at Harbor\u2010UCLA Medical Center Torrance California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology and Center for Androgen\u2010Related Disorders Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Department of Obstetrics &amp; Gynecology, Medical College of Georgia Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-0483","authenticated-orcid":false,"given":"Ricardo","family":"Azziz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology and Center for Androgen\u2010Related Disorders Cedars\u2010Sinai Medical Center Los Angeles California"},{"name":"Department of Obstetrics &amp; Gynecology, Medical College of Georgia Augusta University Augusta Georgia"},{"name":"Department of Obstetrics &amp; Gynecology Albany Medical College Albany New York"},{"name":"Department of Health Policy, Management &amp; Behavior School of Public Health University at Albany SUNY Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.11.070"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2937"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1983.244.6.E632"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00712.2009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00496.2009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2010.01.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(00)90066-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01149-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0963"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.264.2.E197"},{"key":"e_1_2_7_13_1","unstructured":"National Institutes of Health. 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