{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:11:01Z","timestamp":1791591061136,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Detailed studies of Addison's disease resulting from disseminated adrenal histoplasmosis (AH) are not available. We describe the presentation and prognosis of AH and cortisol status before and after antifungal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Single\u2010centre retrospective hospital\u2010based study of 40 consecutive adults with AH [39 males; age (mean\u00a0\u00b1\u00a0SD) 53\u00a0\u00b1\u00a011\u00a0years] was conducted between 2006 and 2018. The median duration of follow\u2010up was 2.5\u00a0years (range 0.2\u201012\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>AH was diagnosed by bilateral adrenal enlargement on CT scan and presence of <jats:italic>Histoplasma<\/jats:italic> by histology and\/or culture of biopsied adrenal tissue. All patients received oral itraconazole and, if required, amphotericin B as per guidelines. ACTH\u2010stimulated serum cortisol (normal\u00a0&gt;\u00a0500\u00a0nmol\/L) was measured in 38 patients at diagnosis and re\u2010tested after one year of antifungal therapy in 21 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three per cent of patients had primary adrenal insufficiency (PAI) and one\u2010third had an adrenal crisis at presentation. HIV antibody was negative in all patients. Of the 29 patients who completed antifungal therapy, 25 (86%) were in remission at last follow\u2010up. Overall, 8 (20%) patients died: three had a sudden death, four had severe histoplasmosis and one died due to adrenal crisis. No patient with PAI became eucortisolemic on re\u2010testing after one year of antifungal therapy. Of the eight patients with normal cortisol at diagnosis, two developed adrenal insufficiency on follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All patients with AH tested negative for HIV antibody. While patients achieved a high rate of clinical remission after antifungal therapy, overall mortality was significant. Cortisol insufficiency did not normalize despite treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13935","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T06:44:36Z","timestamp":1547793876000},"page":"534-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical outcomes and cortical reserve in adrenal histoplasmosis\u2014A retrospective follow\u2010up study of 40 patients"],"prefix":"10.1111","volume":"90","author":[{"given":"Mahaveer","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Chandy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamnay","family":"Bharani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungmei S. 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