{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:20:49Z","timestamp":1780597249254,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine sex\u2010specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography in overweight and obese community\u2010dwelling older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Cross\u2010sectional study of 79 community\u2010dwelling overweight and obese adults (mean\u00a0\u00b1\u00a0SD age 62.8\u00a0\u00b1\u00a07.9\u00a0years; body mass index 32.3\u00a0\u00b1\u00a06.1\u00a0kg\/m<jats:sup>2<\/jats:sup>; 58% women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Peripheral quantitative computed tomography assessed distal radius and tibia trabecular volumetric bone mineral density (vBMD) and proximal radius and tibia cortical vBMD, periosteal circumference, endosteal circumference and stress\u2010strain index. The Homeostatic Model Assessment of Insulin Resistance (HOMA\u2010IR) score was calculated from fasting glucose and insulin values. Lean mass was assessed using dual\u2010energy X\u2010ray absorptiometry. Total minutes of moderate and vigorous physical activity (MVPA) were calculated using the Active Australia Survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Men and women in this cohort had no significant differences in fasting glucose and insulin concentrations, HOMA\u2010IR values\u00a0and diabetes prevalence (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). In women, HOMA\u2010IR was positively correlated with proximal radius periosteal and endosteal circumference (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.331; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.034 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.325; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038, respectively). These associations became nonsignificant in multivariable regression analyses; however, HOMA\u2010IR was negatively associated with proximal radius cortical vBMD (B\u00a0=\u00a0\u22124.79; 95% CI \u22128.66, \u22120.92) after adjusting for age, lean mass and MVPA. All associations between HOMA\u2010IR and bone parameters became nonsignificant in a sensitivity analysis excluding individuals with diabetes, or self\u2010reported use of glucose\u2010lowering medications. There were no associations between HOMA\u2010IR and bone parameters in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Homeostatic Model Assessment of Insulin Resistance was negatively associated with radial cortical vBMD in overweight and obese older women, but not in men. Further studies are needed to clarify sex\u2010specific associations between insulin resistance and bone health in overweight and obese older adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13947","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T14:33:28Z","timestamp":1549463608000},"page":"680-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sex\u2010specific associations between insulin resistance and bone parameters in overweight and obese older adults"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-2731","authenticated-orcid":false,"given":"Jakub","family":"Mesinovic","sequence":"first","affiliation":[{"name":"Department of Medicine School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences Monash University Clayton Victoria 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