{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:05Z","timestamp":1793059985286,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Oral calcium salts are recommended for the treatment of chronic hypoparathyroidism (HypoPT), although dosimetry is variable between individual patients and clinicians. However, patient feedback on calcium salts can be negative, particularly due to gastrointestinal side effects and hypercalciuria\u2010related complications. We begin with a clinical case of a HypoPT patient taking oral calcium salts following thyroid surgery, who requested support in reducing her dose of these with a view to stopping entirely. To evaluate her request, we first describe the usual treatment of HypoPT according to current guidance and then present data from (a) a case note review of a cohort of 24 HypoPT patients managed with a \u201cno calcium\u201d treatment regimen by single physician (b) a comprehensive online survey of HypoPT patients\u2019 treatment and experiences (n = 330). The case note review found that target range serum calcium levels were successfully achieved in all 24 patients since transitioning to a \u201cno calcium\u201d regimen, without any breakthrough hypocalcaemia\u2010related symptoms, the development of new renal stones, the occurrence of calcium\u2010related hospital admissions or the finding of significant hypercalciuria. The online survey identified 36% of HypoPT patients who continued to take activated vitamin D, but had discontinued calcium supplements. HypoPT patients not currently taking calcium reported a significantly lower prevalence of adverse effects and outcomes, both compared with their previous experiences whilst taking calcium and also compared with the 64% of patients who continued to take oral calcium. We conclude that, subject to methodological limitations, there are significant issues of tolerability arising from conventional calcium\u2010based treatment regimens for patients with chronic HypoPT. For selected patients, it may be reasonable to facilitate a managed therapeutic transition to \u201cno calcium\u201d regimen, and we also propose that calcium\u2010based regimes be prospectively evaluated against calcium\u2010free (or calcium\u2010low) alternatives.<\/jats:p>","DOI":"10.1111\/cen.13955","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T05:08:38Z","timestamp":1551157718000},"page":"775-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is calcium supplementation always needed in patients with hypoparathyroidism?"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9777-5317","authenticated-orcid":false,"given":"Ahmed","family":"Al\u2010Sharefi","sequence":"first","affiliation":[{"name":"Sunderland Royal Hospital City Hospitals Sunderland NHS Foundation Trust Sunderland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Glenister","sequence":"additional","affiliation":[{"name":"HypoPara UK East Grinstead West Sussex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Morris","sequence":"additional","affiliation":[{"name":"The Royal Victoria Infirmary Newcastle\u2010upon\u2010Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-8095","authenticated-orcid":false,"given":"Richard","family":"Quinton","sequence":"additional","affiliation":[{"name":"The Royal Victoria Infirmary Newcastle\u2010upon\u2010Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"},{"name":"The Institute of Genetic Medicine University of Newcastle\u2010upon\u2010Tyne Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3907"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01103.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70106-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13895"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1979"},{"key":"e_1_2_10_8_1","unstructured":"The National Institute of Clinical Excellence [NICE Website].Hypertension in adults: diagnosis and management. November 2016.https:\/\/www.nice.org.uk\/guidance\/cg127. Accessed February 6 2019."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.860"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60211-7"},{"key":"e_1_2_10_11_1","unstructured":"Scientific Advisory Committee on Nutrition (SACN) Vitamin D & Health report [Public Health England website] July 21 2016.https:\/\/www.gov.uk\/government\/publications\/sacn-vitamin-d-and-health-report. Accessed February 6 2019."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486075"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1186"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2984"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(05)80506-8"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"41","article-title":"Diet and renal stone formation","volume":"104","author":"Trinchieri A","year":"2013","journal-title":"Minerva Med"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(01)00358-X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650030303"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426507022003286"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/41.2.254"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.13955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.13955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T20:05:09Z","timestamp":1694376309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/cen.13955"],"URL":"https:\/\/doi.org\/10.1111\/cen.13955","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2018-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}