{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T13:03:43Z","timestamp":1753275823329,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000948","name":"Pfizer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We compared growth hormone sensitivity to an insulin\u2010like growth factor I (IGF\u2010I) generation test in children with idiopathic short stature (ISS) and of normal stature (NS) across the birthweight range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six prepubertal children (~7.1\u00a0years) born at term were studied: ISS (n\u00a0=\u00a023; 74% boys) and NS (n\u00a0=\u00a023; 57% boys). Children underwent a modified IGF\u2010I generation test with recombinant human growth hormone (rhGH; 0.05\u00a0mg\/kg\/d) over four consecutive days. Hormonal concentrations were measured at baseline and day 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with idiopathic short stature were 1.90 SDS lighter (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) but had 4.5% more body fat (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0007) than NS children. Overall, decreasing birthweight SDS across the normal range (\u22121.9 to +1.5 SDS) was associated with lower percentage\u00a0IGF\u2010I response to rhGH stimulation in univariable (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.45; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and multivariable models (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a024.6; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). Plasma IGF\u2010I concentrations rose in both groups with rhGH stimulation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). GHBP levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) were suppressed in ISS children (\u221219%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029) but increased among NS children (+18%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), with contrasting responses also observed for leptin and IGFBP\u20101. Further, the increase in insulin concentrations in response to rhGH stimulation was ~3\u2010fold greater in NS children (142% vs 50%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A progressive decrease in birthweight SDS was associated with a reduction in GH sensitivity in both NS and ISS children. Thus, the lower IGF\u2010I response to rhGH stimulation in association with decreasing birthweight indicates that the ISS children at the lower end of the birthweight spectrum may have partial GH resistance, which may contribute to their poorer growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13976","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T19:35:05Z","timestamp":1553542505000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Idiopathic short stature and growth hormone sensitivity in prepubertal children"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-1956","authenticated-orcid":false,"given":"Jos\u00e9 G. 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