{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:45:31Z","timestamp":1790696731646,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is consensus that asymptomatic carriers of <jats:italic>SDHB<\/jats:italic> mutations should undergo periodic surveillance imaging. MRI has the advantage of avoiding radiation exposure but its sensitivity and specificity for detecting phaeochromocytoma and paraganglioma (PPGL) are dependent on sequences performed and expertise of reporting radiologists. We aim to highlight the additional value of diffusion\u2010weighted imaging (DWI) for MR based surveillance, demonstrating DWI's ability to identify small PPGLs at all body sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We presented DWI sequences taken as part of <jats:italic>SDHB<\/jats:italic> surveillance to a radiologist, expert in reporting PPGL screening scans. Areas of high signal on DWI were interrogated using other standard MRI sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We reviewed the MRI scans for 18 <jats:italic>SDHB<\/jats:italic> mutation carriers with a total of 18 histologically proven <jats:italic>SDHB\u2010<\/jats:italic>related tumours and 12 presumed PGLs\/metastatic deposits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DWI sequences identified all 30 lesions. False\u2010positive lesions were excluded by standard sequences. The tumours detected by DWI ranged in size from 5 to 52\u00a0mm. PPGLs were identified on DWI in the abdomen (n\u00a0=\u00a014), adrenal gland (n\u00a0=\u00a01), thorax (n\u00a0=\u00a03), neck (n\u00a0=\u00a02) and bladder (n\u00a0=\u00a02). Additionally, other <jats:italic>SDHB<\/jats:italic>\u2010related tumours (GIST, RCC) were also highlighted by DWI, as were metastatic deposits in the liver and bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary data suggest that DWI has high sensitivity and can identify even small <jats:italic>SDHB<\/jats:italic>\u2010related tumours. If these findings are confirmed in larger series, for all <jats:italic>SDH<\/jats:italic> subunits, it will provide reassurance about identifying small <jats:italic>SDH<\/jats:italic>\u2010related tumours, without exposing patients to the consequences of radiation\u2010based imaging and will secure the role of MRI for surveillance imaging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13980","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T17:29:28Z","timestamp":1554139768000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Diffusion\u2010weighted imaging (DWI) highlights <i>SDHB<\/i>\u2010related tumours: A pilot study"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-9711","authenticated-orcid":false,"given":"Nicola","family":"Tufton","sequence":"first","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital Barts Health NHS Trust London UK"},{"name":"Centre for Endocrinology, Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"White","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital Barts Health NHS Trust London UK"},{"name":"Centre for Endocrinology, Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Sahdev","sequence":"additional","affiliation":[{"name":"Department of Radiology, St Bartholomew\u2019s Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Akker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew\u2019s Hospital Barts Health NHS Trust London UK"},{"name":"Centre for Endocrinology, Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2975"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13246"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9639-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0595"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-4024-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0033"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v8.i9.785"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24285"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0175"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2014.01.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21269"}],"container-title":["Clinical 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