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Bedside tests included three conventional cardiovascular reflex tests of heart rate response to standing up, heart rate response to deep breathing and blood pressure response to standing up. Mean heart rate during the last 2\u00a0minutes of work was used to calculate the maximal aerobic power (VO<jats:sub>2max<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a significantly higher mean reciprocal of the heart rate per second (RR) in TS. Testing for interaction between position and status (TS or control), there were highly significant differences between TS and controls in high\u2010frequency (HF) power, the coefficient of component variation (square root of HF power\/mean RR) and low\u2010frequency (LF): HF ratio, with a dampened decline in vagal activity among TS during standing. Bedside test showed TS had a significantly higher diastolic BP in the supine position compared to controls, and the adaptive rise in BP, when changing to upright position was reduced. VO<jats:sub>2max<\/jats:sub> and self\u2010reported level of physical activity were significantly correlated to systolic ambulatory blood pressure both 24\u2010hour and night diastolic ambulatory blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vagal tone and modulation of the sympathovagal balance during alteration in body position are impaired in TS. These changes can be risk factors for cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13983","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T21:10:04Z","timestamp":1554585004000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Blood pressure, sympathovagal tone, exercise capacity and metabolic status are linked in Turner syndrome"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-2949","authenticated-orcid":false,"given":"Sara","family":"Brun","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine and Medical Research Laboratories Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-1342","authenticated-orcid":false,"given":"Agnethe","family":"Berglund","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8986-6067","authenticated-orcid":false,"given":"Kristian H.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Cardiorespiratory Unit, Great Ormond Street Hospital for Children NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-0516","authenticated-orcid":false,"given":"Britta E.","family":"Hjerrild","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine and Medical Research Laboratories Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-2747","authenticated-orcid":false,"given":"Klavs W.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Diagnostic Centre Regional Hospital Silkeborg Silkeborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-3016","authenticated-orcid":false,"given":"Niels H.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-1720","authenticated-orcid":false,"given":"Claus H.","family":"Gravholt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine and Medical Research Laboratories Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0430"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1059"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11742"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1049"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0558"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01154.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000200509.17947.0f"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4166"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01596.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01045.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1895"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047275.25795.17"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02483.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-24"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-47"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.3.1143"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)00116-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90445-Q"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.8.5.491"},{"key":"e_1_2_8_22_1","first-page":"789","article-title":"Prediction of body water and fat in adult Danes from measurement of electrical impedance. 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