{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:32:11Z","timestamp":1772595131626,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Some features of subjects with Prader\u2010Willi syndrome (PWS) resemble those seen in growth hormone deficiency (GHD). Children with PWS are treated with growth hormone (GH), which has substantially changed their phenotype. Currently, young adults with PWS must discontinue GH after attainment of adult height when they do not fulfil the criteria of adult GHD. Limited information is available about the prevalence of GHD in adults with PWS. This study aimed to investigate the GH\/insulin\u2010like growth factor (IGF\u2010I) axis and the prevalence of GHD in previously GH\u2010treated young adults with PWS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study in 60 young adults with PWS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Serum IGF\u2010I and IGFBP\u20103 levels, GH peak during combined growth hormone\u2010releasing hormone (GHRH)\u2010arginine stimulation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IGF\u2010I was &lt;\u22122 standard deviation scores (SDS) in 2 (3%) patients, and IGFBP\u20103 was within the normal range in all but one patient. Median (IQR) GH peak was 17.8\u00a0\u03bcg\/L (12.2; 29.7) [~53.4\u00a0mU\/L] and below 9\u00a0\u03bcg\/L in 9 (15%) patients. Not one patient fulfilled the criteria for adult GHD (GH peak\u00a0&lt;\u00a09\u00a0\u03bcg\/L and IGF\u2010I\u00a0&lt;\u00a0\u22122 SDS), also when BMI\u2010dependent criteria were used. A higher BMI and a higher fat mass percentage were significantly associated with a lower GH peak. There was no significant difference in GH peak between patients with a deletion or a maternal uniparental disomy (mUPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a large group of previously GH\u2010treated young adults with PWS, approximately 1 in 7 exhibited a GH peak &lt;9\u00a0\u03bcg\/L during a GHRH\u2010arginine test. However, none of the patients fulfilled the consensus criteria for adult GHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13988","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T03:44:02Z","timestamp":1555040642000},"page":"118-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of growth hormone (GH) deficiency in previously GH\u2010treated young adults with Prader\u2010Willi syndrome"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-4284","authenticated-orcid":false,"given":"Stephany H.","family":"Donze","sequence":"first","affiliation":[{"name":"Dutch Growth Research Foundation Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Subdivision of Endocrinology Erasmus University Medical Center Sophia Children\u2019s Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layla","family":"Damen","sequence":"additional","affiliation":[{"name":"Dutch Growth Research Foundation Rotterdam The Netherlands"},{"name":"Department of Pediatrics, Subdivision of Endocrinology Erasmus University Medical Center Sophia Children\u2019s Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jani\u00eblle A. E. M.","family":"van Alfen\u2010van der Velden","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Endocrinology Radboud University Medical Centre, Amalia Children\u2019s Hospital Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bocca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Endocrinology University Medical Center Groningen, Beatrix Children's Hospital Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6589-9788","authenticated-orcid":false,"given":"Martijn J. J.","family":"Finken","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Endocrinology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gera J. 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