{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:01:33Z","timestamp":1792213293113,"version":"4.4.0"},"reference-count":87,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["162608"],"award-info":[{"award-number":["162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Copeptin is secreted in an equimolar amount to arginine vasopressin (AVP) but can easily be measured in plasma or serum with a sandwich immunoassay. The main stimuli for copeptin are similar to AVP, that is an increase in osmolality and a decrease in arterial blood volume and pressure. A high correlation between copeptin and AVP has been shown. Accordingly, copeptin mirrors the amount of AVP in the circulation. Copeptin has, therefore, been evaluated as diagnostic biomarker in vasopressin\u2010dependent disorders of body fluid homeostasis. Disorders of body fluid homeostasis are common and can be divided into hyper\u2010 and hypoosmolar circumstances: the classical hyperosmolar disorder is diabetes insipidus, while the most common hypoosmolar disorder is the syndrome of inappropriate antidiuresis (SIAD). Copeptin measurement has led to a \u201crevival\u201d of the direct test in the differential diagnosis of diabetes insipidus. Baseline copeptin levels, without prior thirsting, unequivocally identify patients with nephrogenic diabetes insipidus. In contrast, for the difficult differentiation between central diabetes insipidus and primary polydipsia, a stimulated copeptin level of 4.9\u00a0pmol\/L upon hypertonic saline infusion differentiates these two entities with a high diagnostic accuracy and is clearly superior to the classical water deprivation test. On the contrary, in the SIAD, copeptin measurement is of only little diagnostic value. Copeptin levels widely overlap in patients with hyponatraemia and emphasize the heterogeneity of the disease. Additionally, a variety of factors lead to unspecific copeptin elevations in the acute setting further complicating its interpretation. The broad use of copeptin as diagnostic marker in hyponatraemia and specifically to detect cancer\u2010related disease in SIADH patients can, therefore, not be recommended.<\/jats:p>","DOI":"10.1111\/cen.13991","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T14:26:03Z","timestamp":1555770363000},"page":"22-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-4685","authenticated-orcid":false,"given":"Julie","family":"Refardt","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism University Hospital Basel Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Winzeler","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism University Hospital Basel Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-0965","authenticated-orcid":false,"given":"Mirjam","family":"Christ\u2010Crain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism University Hospital Basel Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-690X(03)00049-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30031-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)12169-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.05.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90096-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70149-4"},{"issue":"8","key":"e_1_2_7_8_1","first-page":"625","article-title":"Management of the syndrome of inappropriate secretion of antidiuretic hormone","volume":"6","author":"Kinzie BJ","year":"1987","journal-title":"Clin Pharm"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/45.1.98"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2499"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1972.tb01918.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1986.tb01827.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/295299a0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"issue":"32","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"23282","DOI":"10.1016\/S0021-9258(18)50088-0","article-title":"Mechanisms of subcellular cytosolic Ca2+ signaling evoked by stimulation of the vasopressin V1a receptor","volume":"267","author":"Nathanson MH","year":"1992","journal-title":"J Biol Chem"},{"issue":"5","key":"e_1_2_7_16_1","first-page":"R671","article-title":"Osmoregulation and control of vasopressin secretion in healthy humans","volume":"253","author":"Baylis PH","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(88)90625-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-1-35"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0400094"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.69"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.051136"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2295"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1976.76"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01891"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0232"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318033e5da"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21783"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.076"},{"key":"e_1_2_7_29_1","first-page":"w13101","article-title":"The stress hormone copeptin: a new prognostic biomarker in acute illness","volume":"140","author":"Katan M","year":"2010","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0405"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2014.993966"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.136309"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31821a62c2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080140"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01591.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.141689"},{"key":"e_1_2_7_37_1","unstructured":"BeglingerS DreweJ Christ\u2010CrainM.The circadian rhythm of Copeptin the C\u2010terminal portion of Arginin Vasopressin. Poster Presentation SGED Congress Nov 17\u201318 2016 Bern Switzerland. 2016."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.940504"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.224"},{"key":"e_1_2_7_40_1","first-page":"333","article-title":"The regulation of vasopressin function in health and disease","volume":"33","author":"Robertson GL","year":"1976","journal-title":"Recent Prog Horm Res"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-5-721"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.89"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.39.020188.002233"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.100"},{"issue":"246","key":"e_1_2_7_45_1","first-page":"853","article-title":"Thirst in diabetes insipidus: clinical relevance of quantitative assessment","volume":"65","author":"Thompson CJ","year":"1987","journal-title":"Q J Med"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13384"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803760"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103462"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1981"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-7-11-753"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2345"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112243052601"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1040410"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01891"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4507"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1808195"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2046"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0354"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2009.03.004"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.01.027"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0500"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0111"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-1020"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp066837"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.07.006"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90649-8"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.01.013"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.03.013"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1426"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13243"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.11.005"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90224-3"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.31.020180.001531"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080895"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197612)38:6<2575::AID-CNCR2820380651>3.0.CO;2-B"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.8.1191"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1995.tb00907.x"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3638-3"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758834017736210"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9055"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2015.04.002"},{"key":"e_1_2_7_82_1","first-page":"w13270","article-title":"The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseases","volume":"141","author":"Nigro N","year":"2011","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2830"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042743"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006090987"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01250"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13011"},{"key":"e_1_2_7_88_1","article-title":"Adult female with symptomatic AVPR2\u2010related nephrogenic syndrome of inappropriate antidiuresis (NSIAD)","volume":"2018","author":"Hague J","year":"2018","journal-title":"Endocrinol Diabetes Metab Case Rep"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.13991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.13991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:23:23Z","timestamp":1694363003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.13991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,8]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/cen.13991"],"URL":"https:\/\/doi.org\/10.1111\/cen.13991","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,8]]},"assertion":[{"value":"2019-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}