{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:31:18Z","timestamp":1771007478449,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the value of shear wave elastography (SWE) in avoiding repeat fine\u2010needle aspiration of thyroid nodules with nondiagnostic and undetermined cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 232 thyroid nodules with nondiagnostic (n\u00a0=\u00a0132) and undetermined (n\u00a0=\u00a0100) cytology underwent ultrasound (US) and SWE, followed by repeat ultrasound (US)\u2010guided fine\u2010needle aspiration cytology (FNAC). The final diagnosis was based on cytological or pathological findings. The US and SWE characteristics of benign and malignant nodules were compared using the <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010test. The receiver operating characteristic (ROC) curves of the thyroid imaging reporting and data system (TI\u2010RADS) categories from the US and the <jats:italic>E<\/jats:italic><jats:sub>Mean<\/jats:sub> and <jats:italic>E<\/jats:italic><jats:sub>SD<\/jats:sub> from the SWE were graphed, and the areas under the curves (AUCs) were compared using a <jats:italic>Z<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences between the benign and malignant nodules in terms of the echogenicity, shape, margin, calcification and TI\u2010RADS categories (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The differences were significant between the malignant and benign nodules for <jats:italic>E<\/jats:italic><jats:sub>Mean<\/jats:sub> [(34.57\u00a0\u00b1\u00a014.81)\u00a0kPa vs. (19.18\u00a0\u00b1\u00a07.09)\u00a0kPa] and <jats:italic>E<\/jats:italic><jats:sub>SD<\/jats:sub> [(13.68\u00a0\u00b1\u00a013.01)\u00a0kPa vs. (3.97\u00a0\u00b1\u00a02.58)\u00a0kPa] (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Though the difference in the AUCs of <jats:italic>E<\/jats:italic><jats:sub>Mean<\/jats:sub> (0.864) and <jats:italic>E<\/jats:italic><jats:sub>SD<\/jats:sub> (0.876) was not significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.745), they both had higher diagnostic performances in comparison with TI\u2010RADS categories (0.762) (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Moreover, <jats:italic>E<\/jats:italic><jats:sub>SD<\/jats:sub> attained a sensitivity of 100% with a relatively higher specificity of 49.75% when its cut\u2010off value was 3.3\u00a0kPa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Shear wave elastography is a promising imaging method for reducing repeat FNAC for benign thyroid nodules with nondiagnostic and undetermined cytology when using <jats:italic>E<\/jats:italic><jats:sub>SD<\/jats:sub> as an index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.13992","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T14:24:49Z","timestamp":1555770289000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The values of shear wave elastography in avoiding repeat fine\u2010needle aspiration for thyroid nodules with nondiagnostic and undetermined cytology"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0237-2137","authenticated-orcid":false,"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Huadong Hospital Fudan University Shanghai China"},{"name":"Department of Ultrasound, Ruijin Hospital Shanghai Jiaotong University Medical School Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010xin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Huadong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Huadong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Huadong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010hong","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Huadong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Huadong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010wei","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Ruijin Hospital Shanghai Jiaotong University Medical School Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"722","article-title":"Very high prevalence of ultrasound thyroid scan abnormalities in healthy volunteers in Modena, 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