{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:42Z","timestamp":1787014002887,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K08DK109116"],"award-info":[{"award-number":["K08DK109116"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Localization of ectopic ACTH\u2010secreting tumours causing Cushing syndrome (ECS) is essential for clinical management, yet often difficult. [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE PET\/CT ([\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTA\u2010(Tyr\n                      <jats:sup>3<\/jats:sup>\n                      )\u2010octreotate)] is an FDA\u2010approved high\u2010resolution diagnostic tool for imaging neuroendocrine tumours. Data on the clinical utility of [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE in patients with ECS, however, are scarce. The objectives of this study were to determine the efficacy for ECS localization and the clinical benefit of [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective review of all cases with ECS evaluated with [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE from November 2016 through October 2018 at three referral centres. The clinical benefit of [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE was based on detection of new tumours and resultant changes in management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over the study period, 28 patients with ECS underwent [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE: 17 for identification of the primary tumour and 11 during follow\u2010up. [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE identified the suspected primary ECS in 11\/17 patients (65%). Of these, nine patients underwent surgery: eight with confirmed ECS (5 bronchial, 1 thymic, 1 pancreatic and 1 metastatic neuroendocrine tumour of unknown primary origin) and one patient with a false\u2010positive scan (adrenal gland). Of the 11 patients with ECS who underwent [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE evaluation during follow\u2010up, the study led to changes in clinical management in 7\/11 (64%) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>68<\/jats:sup>\n                      Ga]\u2010DOTATATE is sensitive in detecting primary and metastatic ECS, often identifies occult tumours after conventional imaging, and impacts clinical care in the majority of patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14008","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T09:53:36Z","timestamp":1557309216000},"page":"288-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Clinical Impact of [\n                    <sup>68<\/sup>\n                    Ga]\u2010DOTATATE PET\/CT for the Diagnosis and Management of Ectopic Adrenocorticotropic Hormone \u2013 Secreting Tumours"],"prefix":"10.1111","volume":"91","author":[{"given":"Taweesak","family":"Wannachalee","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes University of Michigan Ann Arbor Michigan"},{"name":"Faculty of Medicine Siriraj Hospital, Division of Endocrinology and Metabolism Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina F.","family":"Turcu","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bancos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism &amp; Nutrition Mayo Clinic Rochester Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhammed Amir","family":"Habra","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca M.","family":"Avram","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert 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