{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:59:40Z","timestamp":1787068780537,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anastrozole, an aromatase inhibitor, has been used off\u2010label in males with short stature to delay bone maturation. No studies have examined anastrozole's effect on bone mineral density (BMD) or body composition in children with congenital adrenal hyperplasia (CAH) due to 21\u2010hydroxylase deficiency. Our objective was to evaluate anastrozole's effect on BMD and visceral adipose tissue (VAT) in children with CAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Total body BMD (TBMD) and L2\u2010L4 BMD\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores were adjusted for height\u2010for\u2010age\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores (TBMD\n                      <jats:sub>HAZ<\/jats:sub>\n                      and L2\u2010L4\n                      <jats:sub>HAZ<\/jats:sub>\n                      ). Hydrocortisone doses (mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/d) were averaged over the previous year. Comparison of treated vs not treated with anastrozole used linear regression adjusting for age, pubertal status, sex, CAH type, years on hydrocortisone, BMI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores and bone age\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>We compared 25 children with CAH treated with anastrozole (mean age 11.3 [SD 3.0]\u00a0years, 56% males) vs 31 children with CAH not treated with anastrozole (13.5 [SD 4.6], 29%). Participants underwent a pubertal exam, bone age X\u2010ray and dual X\u2010ray absorptiometry (DXA) scan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Average bone age\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010score of 4.3 SDs on beginning anastrozole decreased to 1.9 SDs at time of DXA exam (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0004) 5.2 (SD 2.2)\u00a0years later. TBMD\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.51), L2\u2010L4 BMD\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.66), VAT (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.38), TBMD\n                      <jats:sub>HAZ<\/jats:sub>\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.66) and L2\u2010L4\n                      <jats:sub>HAZ<\/jats:sub>\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.41) did not differ between children treated vs not treated with anastrozole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anastrozole significantly reduced bone age advancement in children with CAH and advanced bone age (&gt;2SDs) without adverse effects on BMD or VAT. Longitudinal studies of anastrozole in children with CAH are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14009","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T13:03:51Z","timestamp":1557407031000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Use of an aromatase inhibitor in children with congenital adrenal hyperplasia: Impact of anastrozole on bone mineral density and visceral adipose tissue"],"prefix":"10.1111","volume":"91","author":[{"given":"Alyssa","family":"Halper","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Sanchez","sequence":"additional","affiliation":[{"name":"University of Minnesota Masonic Children's Hospital Minneapolis 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