{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:56:51Z","timestamp":1789772211574,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Several studies indicate that patients with primary hyperparathyroidism (PHPT) undergoing parathyroid surgery have improvement in mood and neuropsychological functioning. The current analysis aims to examine the relationship between biochemical and clinical variables and the improvement in depression scores and in specific symptoms, after parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective observational case\u2010control study at a referral centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Patients with PHPT undergoing parathyroidectomy (n\u00a0=\u00a088) or thyroid surgery (n\u00a0=\u00a085).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>The Patient Health Questionnaire\u20109 (PHQ\u20109) was utilized to obtain depression scores at enrolment and 12\u00a0months after surgery. The changes in PHQ\u20109 were analysed and correlated with baseline clinical and biochemical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At enrolment, there was no difference between the groups in the number with a depression diagnosis (PHPT 34.1%, thyroid surgery, 35.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.86). However, baseline PHQ\u20109 scores were significantly higher in PHPT (median 7.5, range 0\u201027) than thyroid surgery patients (median 3.0, range 0\u201018,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Following surgery, all PHQ\u20109 scores, total and symptom group (cognitive, somatic) improved and were no longer different between PHPT (total PHQ\u20109 median 2, range 0\u201016) and thyroid (median 1, range 0\u201014,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.31) groups. Baseline parathyroid hormone level, but not calcium, had a weak relationship with change in PHQ\u20109 score after parathyroid surgery (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003). Baseline PHQ\u20109 score was correlated with change in PHQ\u20109 score at 12\u00a0months after parathyroid surgery (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depression scores improve in both somatic and cognitive domains after parathyroidectomy for PHPT and baseline severity of depression predicts the response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14045","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T03:24:53Z","timestamp":1559791493000},"page":"464-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical characteristics and depression score response after parathyroidectomy in primary hyperparathyroidism"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-3027","authenticated-orcid":false,"given":"Ann E.","family":"Kearns","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Mayo College of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel P.","family":"Espiritu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Mayo College of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Vickers Douglass","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Mayo College of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabin","family":"Thapa","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo College of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Wermers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes, Nutrition, and Metabolism, Mayo College of Medicine Mayo Clinic Rochester 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