{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:03Z","timestamp":1747183863857,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to document current practice in the medical management of paediatric hyperthyroidism in the UK and compare to international recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A 27\u2010question online survey distributed via an electronic newsletter in August 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Responses from 48 members (11%) of the British Society for Paediatric Endocrinology and Diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Information about antithyroid drug (ATD) preference, treatment duration, monitoring of full blood count (FBC), management of neutropaenia, agranulocytosis screening and patient education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carbimazole is favoured by 98% of respondents and a \u201cdose titration\u201d regimen preferred over \u201cblock and replace\u201d (65% vs 29%). TRAbs (thyroid\u2010stimulating hormone receptor antibodies) are used for diagnostic purposes by 85% and by 33% to look for evidence of disease remission. The majority (81%) treat for a minimum of 2\u00a0years before considering a trial off ATD. All respondents reported that they \u201calways\/usually\u201d warn their patients about the risk of agranulocytosis before starting ATD, but written information is \u201crarely\/never\u201d provided by 63%. Sore throat (98%) and fever (92%) are the most commonly cited symptoms used to alert a patient to possible agranulocytosis. FBC is measured prior to treatment by 65% and measured periodically during treatment by 70%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The management of paediatric hyperthyroidism with ATDs in the UK is not consistent with all international recommendations because a block and replace ATD regimen remains widely used. TRAbs are utilized at presentation, but underused for detecting disease remission. National consensus guidelines and written patient information may refine the management of paediatric patients on ATDs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14046","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T08:40:49Z","timestamp":1560156049000},"page":"417-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["How do paediatricians use and monitor antithyroid drugs in the UK? A clinician survey"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-6172","authenticated-orcid":false,"given":"Neil","family":"Lawrence","sequence":"first","affiliation":[{"name":"Sheffield Children\u2019s Hospital NHS Foundation Trust Western Bank Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Cheetham","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Royal Victoria Infirmary Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2390-5593","authenticated-orcid":false,"given":"Charlotte","family":"Elder","sequence":"additional","affiliation":[{"name":"Sheffield Children\u2019s Hospital NHS Foundation Trust Western Bank Sheffield UK"},{"name":"Western Bank The University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03717.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490384"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.26.29"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302013000300006"},{"key":"e_1_2_8_7_1","article-title":"63 Years and 715 Days to the \u201cBoxed Warning\u201d: Unmasking of the Propylthiouracil Problem.","volume":"2010","author":"Rivkees SA","year":"2010","journal-title":"Int J Pediatr Endocrinol."},{"key":"e_1_2_8_8_1","first-page":"CD003420","article-title":"Antithyroid drug regimen for treating Graves' hyperthyroidism","author":"Abraham P","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02169"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"257","article-title":"Standardization of definitions and criteria for causality assessment of adverse drug reactions. Drug\u2010induced blood cytopenias: report of an international consensus meeting","volume":"33","author":"Benichou C","year":"1991","journal-title":"Nouv Rev Fr Hematol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/92.8.455"},{"key":"e_1_2_8_12_1","unstructured":"Formulary Paediatric Committee.BNF for Children. Vol 2018\u20132019. RCPCH Publications Limited.2018."},{"journal-title":"Figshare","article-title":"Paediatric hyperthyroidism \u2010 UK survey of clinicians","author":"Lawrence N","key":"e_1_2_8_13_1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12688"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2802"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.193"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"E1","article-title":"TSI assay utilization: Impact on costs of graves' hyperthyroidism diagnosis","volume":"18","author":"McKee A","year":"2012","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.295"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0450"},{"key":"e_1_2_8_20_1","unstructured":"Medicines for Children.Carbimazole for hyperthyroidism.2016.https:\/\/www.medicinesforchildren.org.uk\/carbimazole-hyperthyroidism. Accessed April 2 2019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689008300505"},{"key":"e_1_2_8_22_1","unstructured":"AgarwalA.Medicinal products containing carbimazole or thiamazole (synonym: methimazole): (1) strengthened advice on contraception and (2) risk of acute pancreatitis [press release]. Direct mailing: Amdipharm Ltd.;2019."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2569"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-017-0172-1"},{"key":"e_1_2_8_25_1","unstructured":"The Committee on Safety of Medicines [World Health Organisation].WHO Pharmaceuticals Newsletter 1999 No. 03&04: Drug surveillance: Anti\u2010thyroid drugs: agranulocytosis: UK.1999.http:\/\/apps.who.int\/medicinedocs\/en\/d\/Js2271e\/2.3.html. Accessed April 2 2019."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02135.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP11339.CR"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13133"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0163278713496630"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03097.x"},{"journal-title":"Figshare","article-title":"Local use of anti\u2010thyroid drugs in Sheffield","author":"Lawrence N","key":"e_1_2_8_31_1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367990"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","unstructured":"CheethamT.Study of two anti\u2010thyroid drug treatment regimens in young people with thyrotoxicosis. Springer Nature. ISRTCN Registry Web site.2011.http:\/\/www.isrctn.com\/ISRCTN82088322. Accessed April 2 2019.","DOI":"10.1186\/ISRCTN82088322"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:37:58Z","timestamp":1694263078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/cen.14046"],"URL":"https:\/\/doi.org\/10.1111\/cen.14046","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}