{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:26:55Z","timestamp":1760909215683,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Constitutional delay of growth and puberty (CDGP) is a frequent variant of the normal leading to short stature and\/or pubertal delay. To distinguish CDGP from hypogonadotropic hypogonadism (HH), we evaluated height, growth and weight pattern of CDGP and HH in the first 5\u00a0years of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>We studied retrospectively height and weight in the first 5\u00a0years (y) of life in 54 boys with CDGP and 8 boys with HH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In boys with CDGP, height\u2010SDS decreased (change \u22120.94 (interquartile range [IQR] \u22121.69 to \u22120.05); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) between birth and 2\u00a0years. BMI\u2010SDS decreased (change \u22120.38 (IQR \u22121.21\u20100.16); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in the same time period. There were no significant changes in height\u2010SDS or BMI\u2010SDS between 2\u00a0years and 5\u00a0years, while height\u2010SDS (change\u00a0+\u00a01.49 (IQR 1.02\u20101.95); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and BMI\u2010SDS (change\u00a0+\u00a00.91 (IQR 0.12\u20101.69); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) increased between pubertal and adult age. In boys with HH, height\u2010SDS and BMI\u2010SDS did not change significantly in the first 5\u00a0years of life. Height\u2010SDS decreased (change \u22121.39 (IQR \u22121.96 to \u22120.67); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) significantly between 5\u00a0years of life and puberty, while there were no significant changes in BMI\u2010SDS in this time period. At pubertal age, BMI\u2010SDS was significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) higher in boys with HH compared with boys with CDGP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Height deflection and weight deflection in CDGP occur already during the first two years of life in contrast to HH. This different pattern of growth and weight might be helpful to distinguish CDGP from HH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14048","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T20:24:33Z","timestamp":1560889473000},"page":"424-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characteristic dynamics of height and weight in preschool boys with constitutional delay of growth and puberty or hypogonadotropic hypogonadism"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-1834","authenticated-orcid":false,"given":"Thomas","family":"Reinehr","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln University of Witten\/Herdecke Datteln 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