{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:37:45Z","timestamp":1781793465990,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the impact of mandatory iodine fortification (IF) on the incidence of nosological subtypes of overt thyrotoxicosis and hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We identified and scrutinized all possible new cases of overt thyrotoxicosis and hypothyroidism in an open cohort in Northern Jutland (n\u00a0=\u00a0309\u00a0434; 1 January 1997) during the years 2014\u20102016. Individual medical history was evaluated to verify and detail the incidence of overt thyroid dysfunction and for classification into nosological subtypes. A number of cases were excluded during final verification due to spontaneous normalization of thyroid function, as they had no medical history suggesting a known condition, which could transiently affect thyroid function (subacute\/silent thyroiditis, PPTD and iatrogenic thyroid dysfunction). An identical survey was conducted in 1997\u20102000 prior to mandatory IF of salt (13\u00a0\u00b5g\/g) that was in effect from year 2001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The standardized incidence rate (SIR) of verified overt thyrotoxicosis decreased markedly from 97.5\/100\u00a0000\/year in 1997\u20102000 to 48.8 in 2014\u20102016 (SIRR: 0.50 [95% CI: 0.45\u20100.56]). This was due to a distinct decrease in the SIR of multinodular toxic goitre (SIRR: 0.18 [0.15\u20100.23]), solitary toxic adenoma (SIRR: 0.26 [0.16\u20100.43]) and to a lesser degree Graves\u2019 disease (SIRR: 0.67 [0.56\u20100.79]). SIR for overt hypothyroidism was unaltered by 2014\u20102016 (SIRR: 1.03 [0.87\u20101.22]). However, age distribution shifted with more young and fewer elderly cases of verified overt hypothyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mandatory IF caused a substantial reduction in SIR of verified overt thyrotoxicosis (especially of nodular origin) while avoiding an increase in SIR of verified overt hypothyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14072","type":"journal-article","created":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T01:58:02Z","timestamp":1565402282000},"page":"652-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Changes in subtypes of overt thyrotoxicosis and hypothyroidism following iodine fortification"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-7850","authenticated-orcid":false,"given":"Mads","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"B\u00fclow Pedersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research and Prevention Bispebjerg\/Frederiksberg Hospital Copenhagen Denmark"},{"name":"Department of Public Health, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Faculty of Medicine Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Perrild","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ovesen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Slagelse Hospital Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Banke Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina H.","family":"Thuesen","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research and Prevention Bispebjerg\/Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Carl\u00e9","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Assessment of iodine deficiency disorders and monitoring their elimination A GUIDE FOR PROGRAMME MANAGERS","author":"World Health Organization","year":"2007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1400400"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430485"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.3.4624"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01121.x"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"1078","article-title":"Amelioration of some pregnancy\u2010associated variations in thyroid function by iodine supplementation","volume":"77","author":"Pedersen KM","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_8_1","unstructured":"JensenHG StrubeM.Bekendtg\u00f8relse Om Tils\u00e6tning Af Jod Til Husholdningssalt Og Salt i Br\u00f8d Og Almindeligt Bagv\u00e6rk m.v. 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