{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:10:00Z","timestamp":1789603800400,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult\u2010onset idiopathic isolated adrenocorticotropic hormone deficiency (id\u2010IAD) is a rare disease with unknown aetiology. Recently, numerous cases of anti\u2010PD\u20101 antibody\u2010induced IAD (PD1\u2010IAD) have been reported, but the clinical course, predictive factors and relationship to id\u2010IAD have not been clarified. Moreover, associations of id\u2010IAD and PD1\u2010IAD with human leucocyte antigen (HLA) require elucidation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical characteristics of 13 Japanese patients with id\u2010IAD and eight Japanese patients with PD1\u2010IAD were analysed, and HLA\u2010typing test was performed for each patient. Allele and haplotype frequencies of the patients were compared to those of healthy Japanese controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the HLA allele and haplotype analyses of id\u2010IAD, the frequencies of HLA\u2010C*14:02, HLA\u2010DPB1*05:01, HLA\u2010DRB1*04:05\u2010DQB1*04:01\u2010DPB1*05:01 and HLA\u2010DRB1*09:01\u2010DQB1*03:03\u2010DPB1*05:01 were significantly increased. On the other hand, HLA alleles account for PD1\u2010IAD susceptibility as follows: HLA\u2010DQB1*06:01, HLA\u2010DPB1*09:01 and HLA\u2010DRB5*01:02. Moreover, protective effect for HLA\u2010C*03:03 was suggested in combined id\u2010IAD and PD1\u2010IAD patients. Comparison of the effects of HLA on id\u2010IAD and PD1\u2010IAD revealed some differences. Alleles or haplotypes frequencies increased in id\u2010IAD group were as follows: HLA\u2010DPB1*05:01, HLA\u2010DRB1*09:01, HLA\u2010DRB4*01:03:02, HLA\u2010DQB1*03:03 and HLA\u2010DRB1*09:01\u2010DQB1*03:03. In clinical settings, hyponatremia, disturbance of consciousness and hypoglycaemia were less frequently seen in patients with PD1\u2010IAD than in patients with id\u2010IAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Distinct clinical characteristics and predisposing HLA allele contributions were proposed between id\u2010IAD and PD1\u2010IAD. Further investigations with greater number of cases are warranted to clarify the detailed mechanisms of id\u2010IAD and PD1\u2010IAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14082","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T03:44:58Z","timestamp":1567136698000},"page":"786-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparative analysis of human leucocyte antigen between idiopathic and anti\u2010PD\u20101 antibody induced isolated adrenocorticotropic hormone deficiency: A pilot study"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-734X","authenticated-orcid":false,"given":"Hidefumi","family":"Inaba","sequence":"first","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ariyasu","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iwakura","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ueda","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Kurimoto","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Uraki","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Takeshima","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Morita","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nishi","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akamizu","sequence":"additional","affiliation":[{"name":"The First Department of Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-0408-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1049"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.24294\/ti.v2.i2.606"},{"key":"e_1_2_10_5_1","first-page":"345","article-title":"Thyrotoxicosis and adrenocortical hormone deficiency during immune\u2010checkpoint inhibitor treatment for malignant melanoma","volume":"32","author":"Ariyasu H","year":"2018","journal-title":"Vivo"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyx018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9074-17"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0238"},{"key":"e_1_2_10_9_1","first-page":"1065","volume-title":"HLA 1991: proceedings of the eleventh international histocompatibility workshop and conference","author":"Imanishi T","year":"1992"},{"key":"e_1_2_10_10_1","unstructured":"Japanese Society for Histocompatibility and Immunogenetics.http:\/\/jshi.umin.ac.jp\/standarization\/JSHI-hyokiallele-2018list.pdf. 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